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Kawada T, Sata Y, Akiyama T, et al. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 2020;225:102657doi: 10.1016/j.autneu.2020.102657.
Kawada, T., Sata, Y., Akiyama, T., Shimizu, S., Sonobe, T., Pearson, J. T., & Sugimachi, M. (2020). Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Autonomic neuroscience : basic & clinical, 225102657. https://doi.org/10.1016/j.autneu.2020.102657
Kawada, Toru, et al. "Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats." Autonomic neuroscience : basic & clinical vol. 225 (2020): 102657. doi: https://doi.org/10.1016/j.autneu.2020.102657
Kawada T, Sata Y, Akiyama T, Shimizu S, Sonobe T, Pearson JT, Sugimachi M. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 2020 Feb 19;225:102657. doi: 10.1016/j.autneu.2020.102657. Epub 2020 Feb 19. PMID: 32097880.
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Auton Neurosci. 2020 Feb 19;225:102657. doi: 10.1016/j.autneu.2020.102657. Epub 2020 Feb 19.

Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats.

Autonomic neuroscience : basic & clinical

Toru Kawada, Yusuke Sata, Tsuyoshi Akiyama, Shuji Shimizu, Takashi Sonobe, James T Pearson, Masaru Sugimachi

Affiliations

  1. Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan. Electronic address: [email protected].
  2. Human Neurotransmitters Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  3. Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.
  4. Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.

PMID: 32097880 DOI: 10.1016/j.autneu.2020.102657

Abstract

Cardiac microdialysis allows the assessment of cardiac efferent vagal nerve activity from myocardial interstitial acetylcholine (ACh) levels with minimal influence on the neural control of the heart; however, a total picture of the baroreflex-mediated myocardial interstitial ACh release including the threshold and saturation pressures has yet to be quantified. In eight anesthetized Wistar-Kyoto rats, we implanted microdialysis probes in the left ventricular free wall and measured the myocardial interstitial ACh release simultaneously with efferent sympathetic nerve activity (SNA) during a carotid sinus baroreceptor pressure input between 60 and 180 mm Hg. The baroreflex-mediated ACh release approximated a positive sigmoid curve, and its threshold and saturation pressures were not significantly different from those of an inverse sigmoid curve associated with the baroreflex-mediated SNA response (threshold: 94.3 ± 8.6 vs. 99.3 ± 6.0 mm Hg; saturation: 150.0 ± 10.3 vs. 158.8 ± 5.8 mm Hg). The sympathetic and vagal systems have certain levels of activities across most of the normal pressure range.

Copyright © 2020 Elsevier B.V. All rights reserved.

Keywords: Acetylcholine; Carotid sinus baroreflex; Open-loop analysis; Sympathetic nerve activity

Conflict of interest statement

Declaration of competing interest The authors declare that there are no conflicts of interest.

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