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Toxicol Rep. 2020 Jan 27;7:217-232. doi: 10.1016/j.toxrep.2020.01.011. eCollection 2020.

Hydroethanolic extract from .

Toxicology reports

Beatriz Martins de Sá Hyacienth, Karyny Roberta Tavares Picanço, Brenda Lorena Sánchez-Ortiz, Luciane Barros Silva, Arlindo César Matias Pereira, Larissa Daniele Machado Góes, Raphaelle Sousa Borges, Rodrigo Cardoso Ataíde, Cleydson Breno Rodrigues Dos Santos, Helison de Oliveira Carvalho, Gloria Melisa Gonzalez Anduaga, Andrés Navarrete, José Carlos Tavares Carvalho

Affiliations

  1. Laboratory of Pharmaceutical Research, Department of Biological Sciences and Health, Federal University of Amapá, Juscelino Kubitschek Street, Marco Zero Campus, Zip Code 68903-419, Macapá, AP, Brazil.
  2. Postgraduate Program in Biodiversity and Biotechnology of the Legal Amazon of the BIONORTE Network, Department of Biological Sciences and Health, Federal University of Amapá, Macapá, AP, Brazil.
  3. Laboratory of Natural Product Pharmacology, Department of Pharmacy, Faculty of Chemistry, National Autonomous University of Mexico, University City, Coyoacán, Zip Code 04510 Mexico City, Mexico.
  4. Federal University of Amapá, Laboratory of Modeling and Computational Chemistry, Department of Biological Sciences and Health, Juscelino Kubitschek Street, Marco Zero Campus, Zip Code 68903-419, Macapá, AP, Brazil.

PMID: 32042599 PMCID: PMC6997909 DOI: 10.1016/j.toxrep.2020.01.011

[No abstract available.]

© 2020 Published by Elsevier B.V.

Keywords: ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; BBB, Brain-blood partition coefficient (C.brain/C.blood); Bergenin; Biotrasformation; EEu, Endopleura uchi stem bark hydroethanolic extract; Endopleura uchi; HAI, Index of Histopathological Changes; HBA, Hydrogen bonding acceptors; HBD, Hydrogen bonding donors; HIA, Human intestinal absorption; Hepatoxity; IAN, Regional Herbarium of the Eastern Amazonian Embrapa; MM, Molecular mass; Nephrotoxity; P-Gp, P-glycoprotein; PPB, Plasma protein binding; Toxicology; hERG, ether-a-go-related human gene

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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