Display options
Cite
Liimatta J, Jääskeläinen J, Karvonen AM, et al. Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years: A Prospective Cohort Study. J Endocr Soc. 2020;4(2):bvaa012doi: 10.1210/jendso/bvaa012.
Liimatta, J., Jääskeläinen, J., Karvonen, A. M., Remes, S., Voutilainen, R., & Pekkanen, J. (2020). Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years: A Prospective Cohort Study. Journal of the Endocrine Society, 4(2), bvaa012. https://doi.org/10.1210/jendso/bvaa012
Liimatta, Jani, et al. "Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years: A Prospective Cohort Study." Journal of the Endocrine Society vol. 4,2 (2020): bvaa012. doi: https://doi.org/10.1210/jendso/bvaa012
Liimatta J, Jääskeläinen J, Karvonen AM, Remes S, Voutilainen R, Pekkanen J. Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years: A Prospective Cohort Study. J Endocr Soc. 2020 Feb 01;4(2):bvaa012. doi: 10.1210/jendso/bvaa012. eCollection 2020 Feb 01. PMID: 32099948; PMCID: PMC7033036.
Copy Download .nbib Format: NLM
Share it on

J Endocr Soc. 2020 Feb 01;4(2):bvaa012. doi: 10.1210/jendso/bvaa012. eCollection 2020 Feb 01.

Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years: A Prospective Cohort Study.

Journal of the Endocrine Society

Jani Liimatta, Jarmo Jääskeläinen, Anne M Karvonen, Sami Remes, Raimo Voutilainen, Juha Pekkanen

Affiliations

  1. Department of Pediatrics, University of Eastern Finland, Kuopio, Finland.
  2. Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
  3. Department of Health Security, National Institute of Health and Welfare, Kuopio, Finland.
  4. Department of Public Health, University of Helsinki, Helsinki, Finland.

PMID: 32099948 PMCID: PMC7033036 DOI: 10.1210/jendso/bvaa012

Abstract

CONTEXT: Adrenarche is a gradual process, but its programming is unknown.

OBJECTIVE: The objective of this article is to examine the trajectory of dehydroepiandrosterone sulfate (DHEAS) from age 1 to 6 years and the associations of early growth with DHEAS concentration by age 6 years.

DESIGN AND PARTICIPANTS: Longitudinal data from a population sample of 78 children (43 girls) with serum samples for DHEAS and insulin-like growth factor 1 (IGF-1) measurements available at ages 1 and 6 years.

MAIN OUTCOME MEASURE: Serum DHEAS concentration at age 6 years.

RESULTS: DHEAS concentration at age 1 year correlated with DHEAS concentration at age 6 years (r = 0.594,

CONCLUSIONS: Higher serum DHEAS concentrations already at age 1 year are associated with those at age 6 years. Also, shorter birth length and rapid catch-up growth in length by age 1 year are associated with higher DHEAS concentrations at age 6 years. These results corroborate the early origin of adrenarche and strongly suggest that part of adrenarchal programming already takes place by the end of infancy.

© Endocrine Society 2020.

Keywords: adrenarche; birth size; dehydroepiandrosterone sulfate; growth; insulin-like growth factor 1

References

  1. Pediatr Res. 2017 Aug;82(2):285-289 - PubMed
  2. Arch Dis Child. 1969 Jun;44(235):291-303 - PubMed
  3. J Clin Endocrinol Metab. 2002 Jan;87(1):398-403 - PubMed
  4. J Clin Endocrinol Metab. 2003 Mar;88(3):1389-93 - PubMed
  5. Eur J Pediatr. 1995 May;154(5):346-52 - PubMed
  6. Am J Clin Nutr. 2009 Nov;90(5):1321-8 - PubMed
  7. J Clin Endocrinol Metab. 1997 May;82(5):1390-6 - PubMed
  8. J Clin Endocrinol Metab. 2014 Oct;99(10):3889-94 - PubMed
  9. Arch Dis Child. 1995 Oct;73(4):287-93 - PubMed
  10. J Clin Endocrinol Metab. 2005 Apr;90(4):2015-21 - PubMed
  11. J Clin Endocrinol Metab. 2006 Nov;91(11):4645-9 - PubMed
  12. Int J Obes (Lond). 2006 Dec;30 Suppl 4:S11-7 - PubMed
  13. J Clin Endocrinol Metab. 1968 Nov;28(11):1525-33 - PubMed
  14. Horm Res. 2008;70(5):257-67 - PubMed
  15. J Clin Endocrinol Metab. 1999 Nov;84(11):3936-44 - PubMed
  16. J Pediatr. 2002 Oct;141(4):477-82 - PubMed
  17. Horm Res. 1999;52(5):221-9 - PubMed
  18. Front Neuroendocrinol. 2001 Jul;22(3):185-212 - PubMed
  19. Pediatrics. 2009 Aug;124(2):e329-38 - PubMed
  20. J Clin Endocrinol Metab. 1999 Jun;84(6):2037-42 - PubMed
  21. Endocr Res. 1998 Aug-Nov;24(3-4):969-73 - PubMed
  22. J Clin Endocrinol Metab. 1996 Nov;81(11):3892-7 - PubMed
  23. Am J Clin Nutr. 2013 Feb;97(2):318-25 - PubMed
  24. Clin Endocrinol (Oxf). 2018 Feb;88(2):234-242 - PubMed
  25. Arch Dis Child. 1970 Feb;45(239):13-23 - PubMed
  26. J Pediatr. 2009 Jun;154(6):882-7 - PubMed
  27. Endocrinol Metab Clin North Am. 1996 Sep;25(3):573-90 - PubMed
  28. J Clin Endocrinol Metab. 2004 Jun;89(6):2647-51 - PubMed
  29. Beitr Pathol. 1973 Dec;150(4):357-77 - PubMed
  30. Ann Med. 2013 Sep;45(5-6):446-54 - PubMed
  31. Horm Res Paediatr. 2017;87(1):15-22 - PubMed
  32. Clin Endocrinol (Oxf). 2000 Jul;53(1):69-76 - PubMed
  33. J Pediatr. 2017 Jul;186:72-77 - PubMed
  34. Endocr Rev. 1998 Feb;19(1):55-79 - PubMed
  35. Ann Med. 2011 May;43(3):235-48 - PubMed
  36. J Endocrinol. 2012 Aug;214(2):133-43 - PubMed
  37. J Clin Endocrinol Metab. 2002 Mar;87(3):1041-4 - PubMed
  38. Allergy. 2006 Apr;61(4):407-13 - PubMed
  39. J Pediatr Endocrinol Metab. 2013;26(3-4):215-21 - PubMed

Publication Types