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Rams TE, Sautter JD, van Winkelhoff AJ. Comparative In Vitro Resistance of Human Periodontal Bacterial Pathogens to Tinidazole and Four Other Antibiotics. Antibiotics (Basel). 2020;9(2)doi: 10.3390/antibiotics9020068.
Rams, T. E., Sautter, J. D., & van Winkelhoff, A. J. (2020). Comparative In Vitro Resistance of Human Periodontal Bacterial Pathogens to Tinidazole and Four Other Antibiotics. Antibiotics (Basel, Switzerland), 9(2), . https://doi.org/10.3390/antibiotics9020068
Rams, Thomas E, et al. "Comparative In Vitro Resistance of Human Periodontal Bacterial Pathogens to Tinidazole and Four Other Antibiotics." Antibiotics (Basel, Switzerland) vol. 9,2 (2020). doi: https://doi.org/10.3390/antibiotics9020068
Rams TE, Sautter JD, van Winkelhoff AJ. Comparative In Vitro Resistance of Human Periodontal Bacterial Pathogens to Tinidazole and Four Other Antibiotics. Antibiotics (Basel). 2020 Feb 07;9(2). doi: 10.3390/antibiotics9020068. PMID: 32046045; PMCID: PMC7168304.
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Antibiotics (Basel). 2020 Feb 07;9(2). doi: 10.3390/antibiotics9020068.

Comparative In Vitro Resistance of Human Periodontal Bacterial Pathogens to Tinidazole and Four Other Antibiotics.

Antibiotics (Basel, Switzerland)

Thomas E Rams, Jacqueline D Sautter, Arie J van Winkelhoff

Affiliations

  1. Department of Periodontology and Oral Implantology, Temple University School of Dentistry, Philadelphia, PA 19140, USA.
  2. Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
  3. Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
  4. Department of Periodontology, University of Groningen, University Medical Center Groningen, Center for Dentistry and Oral Hygiene, 9713 GZ Groningen, The Netherlands.

PMID: 32046045 PMCID: PMC7168304 DOI: 10.3390/antibiotics9020068

Abstract

The in vitro resistance of selected red/orange complex periodontal pathogens to tinidazole was compared with four other antibiotics. Subgingival biofilm samples from 88 adults with severe periodontitis were anaerobically incubated on enriched Brucella blood agar with and without supplementation with tinidazole (16 mg/L), metronidazole (16 mg/L), amoxicillin (8 mg/L), doxycycline (4 mg/L), or clindamycin (4 mg/L). Growth of

Keywords: amoxicillin; anti-infective agents; clindamycin; doxycycline; drug resistance; in vitro; metronidazole; periodontal pocket; periodontitis; tinidazole

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