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Cancers (Basel). 2020 Feb 24;12(2). doi: 10.3390/cancers12020520.

Intratumoral Heterogeneity and Longitudinal Changes in Gene Expression Predict Differential Drug Sensitivity in Newly Diagnosed and Recurrent Glioblastoma.

Cancers

Ella L Kim, Maxim Sorokin, Sven Rainer Kantelhardt, Darius Kalasauskas, Bettina Sprang, Julian Fauss, Florian Ringel, Andrew Garazha, Eugene Albert, Nurshat Gaifullin, Christian Hartmann, Nicole Naumann, Sven-Ernö Bikar, Alf Giese, Anton Buzdin

Affiliations

  1. Clinic for Neurosurgery, Laboratory of Experimental Neurooncology, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany.
  2. Institute of Personalized Medicine, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
  3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
  4. Omicsway Corp., 340 S Lemon Ave, 6040, Walnut, CA 91789, USA.
  5. Clinic for Neurosurgery, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany.
  6. Department of Pathology, Faculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia.
  7. Department of Neuropathology, Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany.
  8. StarSEQ GmbH, Joh.-Joachim-Becher-Weg 30a, 55128 Mainz, Germany.
  9. OrthoCentrum Hamburg, Hansastrasse 1, 20149 Hamburg, Germany.
  10. Oncobox Ltd., 121205 Moscow, Russia.
  11. Moscow Institute of Physics and Technology, 141701 Moscow Region, Russia.

PMID: 32102350 PMCID: PMC7072286 DOI: 10.3390/cancers12020520

[No abstract available.]

Keywords: gene expression; glioblastoma; glioblastoma stem cells; molecular pathways; recurrent glioblastoma; target anti-cancer therapy; transcriptomics

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