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Simo Es Covello LH, Gava-Brandolis MG, Castro MG, et al. Vasopressors and Nutrition Therapy: Safe Dose for the Outset of Enteral Nutrition?. Crit Care Res Pract. 2020;2020:1095693doi: 10.1155/2020/1095693.
Simo Es Covello, L. H., Gava-Brandolis, M. G., Castro, M. G., Dos Santos Netos, M. F., Manzanares, W., & Toledo, D. O. (2020). Vasopressors and Nutrition Therapy: Safe Dose for the Outset of Enteral Nutrition?. Critical care research and practice, 20201095693. https://doi.org/10.1155/2020/1095693
Simo Es Covello, Luís Henrique, et al. "Vasopressors and Nutrition Therapy: Safe Dose for the Outset of Enteral Nutrition?." Critical care research and practice vol. 2020 (2020): 1095693. doi: https://doi.org/10.1155/2020/1095693
Simo Es Covello LH, Gava-Brandolis MG, Castro MG, Dos Santos Netos MF, Manzanares W, Toledo DO. Vasopressors and Nutrition Therapy: Safe Dose for the Outset of Enteral Nutrition?. Crit Care Res Pract. 2020 Feb 10;2020:1095693. doi: 10.1155/2020/1095693. eCollection 2020. PMID: 32104602; PMCID: PMC7035530.
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Crit Care Res Pract. 2020 Feb 10;2020:1095693. doi: 10.1155/2020/1095693. eCollection 2020.

Vasopressors and Nutrition Therapy: Safe Dose for the Outset of Enteral Nutrition?.

Critical care research and practice

Luís Henrique Simo Es Covello, Marcella Giovana Gava-Brandolis, Melina Gouveia Castro, Martins Fidelis Dos Santos Netos, William Manzanares, Diogo Oliveira Toledo

Affiliations

  1. Department of Critical Care of Barretos Cancer Hospital, Barretos, Brazil.
  2. Department of Research of Hospital Sa˜o Luis Itaim, Sa˜o Paulo, Brazil.
  3. Department of Education of Hospital Israelita Albert Einstein, Sa˜o Paulo, Brazil.
  4. Department of Science Information of Barretos Cancer Hospital, Barretos, Brazil.
  5. Department of Critical Care, University Hospital of Universidad de la Republica (UDELAR), Montevideo, Uruguay.
  6. Department of Critical Care of Hospital Israelita Albert Einstein, Sa˜o Paulo, Brazil.

PMID: 32104602 PMCID: PMC7035530 DOI: 10.1155/2020/1095693

Abstract

BACKGROUND AND AIMS: Patients with hemodynamic instability need to receive intensive treatment as fluid replacement and vasoactive drugs. In the meantime, it is supposed to initiate nutritional therapy within 24 to 48 hours after admission to the intensive care unit (ICU), as an essential part of patient's intensive care and better outcomes. However, there are many controversies tangential to the prescription of enteral nutrition (EN) concomitant to the use of vasopressor and its doses. In this way, the present study aimed to identify what the literature presents of evidence to guide the clinical practice concerning the safe dose of vasopressors for the initiation of nutritional therapy in critically ill patients.

METHODS: This review was carried out in PubMed, ProQuest, Web of Science, and Medline databases. The descriptors were used to perform the search strategy: Critical Care, Intensive Care Units, Vasoconstrictor Agents, and Enteral Nutrition. Inclusion criteria were patients of both genders, over 18 years of age, using vasoactive drugs, with the possibility of receiving EN therapy, and articles written in English, Portuguese, and Spanish. In addition, exclusion criteria were case reports, non-papers, and repeated papers.

RESULTS: 10 articles met our inclusion criteria.

CONCLUSION: It was observed that there are many controversies about the supply of EN in critically ill patients using vasopressor, especially about the safe dose, and it was not possible to identify a cutoff value for the beginning therapy. Despite the drug doses, clinical signs are still the most important parameters in the evaluation of EN tolerance.

Copyright © 2020 Luís Henrique Simo˜es Covello et al.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

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