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Lakkaraju A, Umapathy A, Tan LX, et al. The cell biology of the retinal pigment epithelium. Prog Retin Eye Res. 2020;100846doi: 10.1016/j.preteyeres.2020.100846.
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020). The cell biology of the retinal pigment epithelium. Progress in retinal and eye research, 100846. https://doi.org/10.1016/j.preteyeres.2020.100846
Lakkaraju, Aparna, et al. "The cell biology of the retinal pigment epithelium." Progress in retinal and eye research vol. (2020): 100846. doi: https://doi.org/10.1016/j.preteyeres.2020.100846
Lakkaraju A, Umapathy A, Tan LX, Daniele L, Philp NJ, Boesze-Battaglia K, Williams DS. The cell biology of the retinal pigment epithelium. Prog Retin Eye Res. 2020 Feb 24;100846. doi: 10.1016/j.preteyeres.2020.100846. Epub 2020 Feb 24. PMID: 32105772.
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Prog Retin Eye Res. 2020 Feb 24;100846. doi: 10.1016/j.preteyeres.2020.100846. Epub 2020 Feb 24.

The cell biology of the retinal pigment epithelium.

Progress in retinal and eye research

Aparna Lakkaraju, Ankita Umapathy, Li Xuan Tan, Lauren Daniele, Nancy J Philp, Kathleen Boesze-Battaglia, David S Williams

Affiliations

  1. Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
  2. Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  3. Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  4. Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
  5. Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: [email protected].

PMID: 32105772 DOI: 10.1016/j.preteyeres.2020.100846

Abstract

The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new technologies such as live-cell imaging have resulted in major advancement in our understanding of areas such as the daily phagocytosis and clearance of photoreceptor outer segment tips, autophagy, endolysosome function, and the metabolic interplay between the RPE and photoreceptors. In this review, we aim to integrate these studies with an emphasis on appropriate models and techniques to investigate RPE cell biology and metabolism, and discuss how RPE cell biology informs our understanding of retinal disease.

Copyright © 2020 Elsevier Ltd. All rights reserved.

Keywords: Autophagy; Endosomes; Lysosomes; Metabolism; Organelles; Phagocytosis; Phagosome maturation

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

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