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Mrozikiewicz-Rakowska B, Malinowski M, Nehring P, et al. The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer. Arch Med Sci. 2019;16(1):112-117doi: 10.5114/aoms.2017.70329.
Mrozikiewicz-Rakowska, B., Malinowski, M., Nehring, P., Bartkowiak-Wieczorek, J., Bogacz, A., Żurawińska-Grzelka, E., Krasnodębski, P., Muszyński, J., Grzela, T., Przybyłkowski, A., & Czupryniak, L. (2020). The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer. Archives of medical science : AMS, 16(1), 112-117. https://doi.org/10.5114/aoms.2017.70329
Mrozikiewicz-Rakowska, Beata, et al. "The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer." Archives of medical science : AMS vol. 16,1 (2020): 112-117. doi: https://doi.org/10.5114/aoms.2017.70329
Mrozikiewicz-Rakowska B, Malinowski M, Nehring P, Bartkowiak-Wieczorek J, Bogacz A, Żurawińska-Grzelka E, Krasnodębski P, Muszyński J, Grzela T, Przybyłkowski A, Czupryniak L. The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer. Arch Med Sci. 2019 Sep 26;16(1):112-117. doi: 10.5114/aoms.2017.70329. eCollection 2020. PMID: 32051713; PMCID: PMC6963158.
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Arch Med Sci. 2019 Sep 26;16(1):112-117. doi: 10.5114/aoms.2017.70329. eCollection 2020.

The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer.

Archives of medical science : AMS

Beata Mrozikiewicz-Rakowska, Marian Malinowski, Piotr Nehring, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Ewa Żurawińska-Grzelka, Przemysław Krasnodębski, Jacek Muszyński, Tomasz Grzela, Adam Przybyłkowski, Leszek Czupryniak

Affiliations

  1. Department of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
  2. 1 Department of Obstetrics and Gynecology, Medical Centre of Postgraduate Education, Warsaw, Poland.
  3. Department of Gastroenterology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
  4. Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, Poznan, Poland.
  5. Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibers and Medicinal Plants, Poznan, Poland.
  6. Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
  7. Cell Molecular Biology Laboratory, Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.

PMID: 32051713 PMCID: PMC6963158 DOI: 10.5114/aoms.2017.70329

Abstract

INTRODUCTION: Colorectal cancer (CRC) is one of the most frequently diagnosed tumors in Western countries. CRC is a heterogeneous group of tumors with regards to its molecular pathogenesis and genetic factors. Both genetic variations and anthropometric factors may affect morbidity in CRC patients. The aim of this study was to assess the impact of multidrug resistance 1/ATP-binding cassette sub-family B member 1 gene (MDR1/ABCB1) polymorphism rs1045642 and general anthropometric factors on the CRC risk.

MATERIAL AND METHODS: The study included 250 patients who underwent colonoscopy and polypectomy between 2006 and 2013 in a single endoscopy unit in Warsaw, Poland.

RESULTS: The CRC was diagnosed in 50 individuals, and 200 patients were included in the control group. Cases and controls were matched for mean age and sex (

CONCLUSIONS: The MDR1/ABCB1 gene polymorphism rs 1045642 may be involved in the pathogenesis of CRC and this relationship may be sex-specific for males. However, further population studies are necessary to assess this relationship.

Copyright: © 2017 Termedia & Banach.

Keywords: colorectal cancer; polymorphism; risk factors; rs 1045642

Conflict of interest statement

The authors declare no conflict of interest.

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