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Basic Clin Androl. 2020 Feb 13;30:2. doi: 10.1186/s12610-020-0099-1. eCollection 2020.

RISUG.

Basic and clinical andrology

Barkha Khilwani, Ayesha Badar, Abdul S Ansari, Nirmal K Lohiya

Affiliations

  1. Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, 302004 India.

PMID: 32082579 PMCID: PMC7017607 DOI: 10.1186/s12610-020-0099-1

Abstract

Even after decades of research men still lack reliable and reversible contraceptive methods comparable to female methods of contraception. Traditional methods of male contraception present a high failure rate and also involve high risk both when used for contraception and for protection against sexually transmitted diseases. Various chemical, hormonal, immunological, vas based and herbal methods of contraception have been examined by scientists world over during the past four decades. Among the possible lead approaches, exogenous hormonal contraception, either alone or in combination with progesterone or antiandrogen, is being viewed at low profile because of their insufficiency in inducing uniform suppression of spermatogenesis and steroid related long term complications. As an alternative to vasectomy, among various intravasal devices being examined, RISUG

© The Author(s). 2020.

Keywords: Azoospermia; Clinical trials; Male contraception; RISUG®; Reversibility

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

References

  1. Urology. 2006 Jul;68(1):9-14 - PubMed
  2. Contraception. 1990 Mar;41(3):333-9 - PubMed
  3. Contraception. 1990 Aug;42(2):215-23 - PubMed
  4. J Urol. 1995 Dec;154(6):2065-9 - PubMed
  5. J Androl. 2003 Jul-Aug;24(4):501-9 - PubMed
  6. Contraception. 1997 Oct;56(4):245-50 - PubMed
  7. Postepy Hig Med Dosw (Online). 2005;59:523-34 - PubMed
  8. Contraception. 2003 Jan;67(1):73-8 - PubMed
  9. Contraception. 1998 Feb;57(2):125-32 - PubMed
  10. Int J Androl. 2000 Feb;23(1):36-42 - PubMed
  11. Urology. 2009 Jan;73(1):134-6 - PubMed
  12. Nat Clin Pract Endocrinol Metab. 2006 Jan;2(1):32-41 - PubMed
  13. J Urol. 1991 Feb;145(2):341-4 - PubMed
  14. Contraception. 1999 Feb;59(2):137-44 - PubMed
  15. Contraception. 1993 Oct;48(4):367-75 - PubMed
  16. Mol Cell Endocrinol. 2006 May 16;250(1-2):66-9 - PubMed
  17. Reprod Toxicol. 2018 Oct;81:84-92 - PubMed
  18. Asian J Androl. 2005 Jun;7(2):195-204 - PubMed
  19. Fertil Steril. 1981 Aug;36(2):222-4 - PubMed
  20. Contraception. 1985 Jul;32(1):109-18 - PubMed
  21. Indian J Med Res. 2018 Dec;148(Suppl):S1-S9 - PubMed
  22. J Reprod Fertil. 1981 Nov;63(2):539-42 - PubMed
  23. Reprod Toxicol. 2013 Apr;36:53-9 - PubMed
  24. Contraception. 2011 Apr;83(4):310-5 - PubMed
  25. Contraception. 1979 Nov;20(5):467-73 - PubMed
  26. Int J Androl. 2010 Feb;33(1):e198-206 - PubMed
  27. Ther Adv Endocrinol Metab. 2019 Mar 14;10:2042018819834846 - PubMed
  28. Asian J Androl. 2017 Jul-Aug;19(4):389-395 - PubMed
  29. Urol Clin North Am. 2014 Feb;41(1):145-61 - PubMed
  30. Soc Sci Med. 2016 Jul;161:1-12 - PubMed
  31. Contraception. 1990 Sep;42(3):337-47 - PubMed
  32. Med Hypotheses. 2005;65(1):61-4 - PubMed
  33. Allergy. 1998 Nov;53(11):1107-8 - PubMed
  34. Indian J Med Res. 2014 Nov;140 Suppl:S63-72 - PubMed
  35. BMJ. 2005 Feb 5;330(7486):296-9 - PubMed
  36. Med Hypotheses. 2009 Aug;73(2):150-2 - PubMed
  37. Fertil Steril. 2000 May;73(5):923-36 - PubMed
  38. Indian J Med Res. 2019 Jul;150(1):81-86 - PubMed
  39. Andrology. 2016 Mar;4(2):306-13 - PubMed
  40. J Health Psychol. 2016 May;21(5):788-97 - PubMed
  41. Fam Plann Perspect. 1993 Mar-Apr;25(2):67-73 - PubMed
  42. J Fam Plann Reprod Health Care. 2009 Jul;35(3):161-5 - PubMed
  43. Asian J Androl. 2007 Mar;9(2):221-7 - PubMed
  44. Gynecol Obstet Fertil. 2005 Jan-Feb;33(1-2):2-10 - PubMed
  45. Nat Rev Urol. 2013 Apr;10(4):195-205 - PubMed
  46. BMJ Sex Reprod Health. 2019 Sep 19;: - PubMed
  47. Fertil Steril. 1988 Mar;49(3):527-33 - PubMed
  48. J Reprod Fertil. 1982 May;65(1):9-13 - PubMed
  49. Contraception. 1998 Oct;58(4):227-31 - PubMed
  50. Cult Health Sex. 2015;17(3):312-25 - PubMed
  51. Stud Fam Plann. 1995 May-Jun;26(3):140-53 - PubMed
  52. Int J Toxicol. 2018 Nov 1;:1091581818809473 - PubMed
  53. Indian J Exp Biol. 2005 Nov;43(11):1042-7 - PubMed
  54. Protein Sci. 2014 Jul;23(7):857-68 - PubMed
  55. Contraception. 1998 Aug;58(2):119-28 - PubMed

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