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Lv S, Wang Z, Sun X, et al. Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler. Front Psychiatry. 2020;11:51doi: 10.3389/fpsyt.2020.00051.
Lv, S., Wang, Z., Sun, X., Jin, H., Liu, J., Deng, F., Lv, Y., Jia, M., Guo, Z. N., & Yang, Y. (2020). Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler. Frontiers in psychiatry, 1151. https://doi.org/10.3389/fpsyt.2020.00051
Lv, Shan, et al. "Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler." Frontiers in psychiatry vol. 11 (2020): 51. doi: https://doi.org/10.3389/fpsyt.2020.00051
Lv S, Wang Z, Sun X, Jin H, Liu J, Deng F, Lv Y, Jia M, Guo ZN, Yang Y. Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler. Front Psychiatry. 2020 Feb 19;11:51. doi: 10.3389/fpsyt.2020.00051. eCollection 2020. PMID: 32140114; PMCID: PMC7042385.
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Front Psychiatry. 2020 Feb 19;11:51. doi: 10.3389/fpsyt.2020.00051. eCollection 2020.

Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler.

Frontiers in psychiatry

Shan Lv, Zan Wang, Xin Sun, Hang Jin, Jia Liu, Fang Deng, Yudan Lv, Meiyan Jia, Zhen-Ni Guo, Yi Yang

Affiliations

  1. Department of Neurology, The First Hospital of Jilin University, Changchun, China.
  2. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
  3. Clinical Trial and Research Center for Stroke, Department of Neurology, The First Hospital of Jilin University, Changchun, China.

PMID: 32140114 PMCID: PMC7042385 DOI: 10.3389/fpsyt.2020.00051

Abstract

BACKGROUND: Patients with idiopathic rapid eye movement behavior disorder (IRBD) have been suggested to exhibit altered cerebral perfusion and abnormal cerebral blood flow, which imply a possibility of cerebral autoregulation (CA) impairment. We aimed to investigate the dynamic CA (dCA) in patients with IRBD during wakefulness and to explore the correlations between dCA parameters and clinical measurements.

METHODS: We assessed the dCA capability of 30 patients with IRBD and 36 sex- and age-matched healthy controls by using transcranial Doppler and finger plethysmography. CA function was evaluated by transfer function analysis based on spontaneous oscillation of cerebral blood flow and arterial blood pressure. Transfer function parameters (phase difference and gain) were used to quantify the CA.

RESULTS: No significant differences were observed between the right and left middle cerebral artery dCA parameters (phase difference and gain) of both groups. Patients with IRBD had significantly lower phase difference than the healthy controls, indicating their impaired CA capability. Besides, the value of gain in patients with IRBD was higher than the healthy controls, but the difference did not reach statistical level.

CONCLUSIONS: CA function is compromised in patients with IRBD during wakefulness, which might be an intermediate link between IRBD and neurological symptoms.

Copyright © 2020 Lv, Wang, Sun, Jin, Liu, Deng, Lv, Jia, Guo and Yang.

Keywords: cerebral autoregulation; cerebral hemodynamics; idiopathic rapid eye movement sleep behavior disorder; transcranial Doppler; transfer function

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