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Mathur K, Agrawal RK, Nagpure S, et al. Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients. J Family Med Prim Care. 2020;9(1):69-71doi: 10.4103/jfmpc.jfmpc_329_19.
Mathur, K., Agrawal, R. K., Nagpure, S., & Deshpande, D. (2020). Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients. Journal of family medicine and primary care, 9(1), 69-71. https://doi.org/10.4103/jfmpc.jfmpc_329_19
Mathur, Kushagra, et al. "Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients." Journal of family medicine and primary care vol. 9,1 (2020): 69-71. doi: https://doi.org/10.4103/jfmpc.jfmpc_329_19
Mathur K, Agrawal RK, Nagpure S, Deshpande D. Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients. J Family Med Prim Care. 2020 Jan 28;9(1):69-71. doi: 10.4103/jfmpc.jfmpc_329_19. eCollection 2020 Jan. PMID: 32110567; PMCID: PMC7014832.
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J Family Med Prim Care. 2020 Jan 28;9(1):69-71. doi: 10.4103/jfmpc.jfmpc_329_19. eCollection 2020 Jan.

Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients.

Journal of family medicine and primary care

Kushagra Mathur, Rajat Kumar Agrawal, Shailesh Nagpure, Deepali Deshpande

Affiliations

  1. Medical Intern, Department of Pharmacology, Jawaharlal Nehru Medical College, Sawangi, Maharashtra, India.
  2. Professor, Department of Pharmacology, Jawaharlal Nehru Medical College, Sawangi, Maharashtra, India.
  3. Laboratory Assistant, Central Research Laboratory, Jawaharlal Nehru Medical College, Sawangi, Maharashtra, India.

PMID: 32110567 PMCID: PMC7014832 DOI: 10.4103/jfmpc.jfmpc_329_19

Abstract

INTRODUCTION: Incidence of diabetes mellitus has increased over the past few years, mainly due to our eating habits and physical inactivity. This also includes the use of artificial sweetening agents which have broadly replaced other forms of sugars and have shown a paradoxical, negative effect on blood glucose. Ingestion of these artificial sweeteners (AS) results in the release of insulin from pancreas which is mistaken for glucose (due to their sweet taste). This increases the levels of insulin in blood eventually leading to decreased receptor activity due to insulin resistance.

METHODOLOGY: It is a crosssectional study that was conducted on patients diagnosed with type-2 diabetes mellitus of a tertiary care hospital in Central India. All the diabetics that presented in the OPD were divided into 2 groups based on whether they use AS (group A) or not (group B). Insulin resistance was calculated for each group using HOMA-IR and graphs were plotted.

RESULTS: The HOMAIR values for Group A and B ranged from 0.9-24.33 and 0.12-10.83 with mean values 7.39 and 2.6, respectively, showing that the ones who used AS had a higher insulin resistance. The study also showed that the duration of use of artificial sweeteners had a direct impact on insulin resistance.

Copyright: © 2020 Journal of Family Medicine and Primary Care.

Keywords: Artificial sweeteners; HOMA-IR; diabetes mellitus; glucose metabolism; insulin resistance

Conflict of interest statement

There are no conflicts of interest.

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