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Fujita S, Honda K, Yamaguchi M, et al. Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks. J Poult Sci. 2019;56(4):270-276doi: 10.2141/jpsa.0180127.
Fujita, S., Honda, K., Yamaguchi, M., Fukuzo, S., Saneyasu, T., & Kamisoyama, H. (2019). Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks. The journal of poultry science, 56(4), 270-276. https://doi.org/10.2141/jpsa.0180127
Fujita, Shoichi, et al. "Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks." The journal of poultry science vol. 56,4 (2019): 270-276. doi: https://doi.org/10.2141/jpsa.0180127
Fujita S, Honda K, Yamaguchi M, Fukuzo S, Saneyasu T, Kamisoyama H. Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks. J Poult Sci. 2019 Oct 25;56(4):270-276. doi: 10.2141/jpsa.0180127. PMID: 32055224; PMCID: PMC7005399.
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J Poult Sci. 2019 Oct 25;56(4):270-276. doi: 10.2141/jpsa.0180127.

Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks.

The journal of poultry science

Shoichi Fujita, Kazuhisa Honda, Mika Yamaguchi, Satoshi Fukuzo, Takaoki Saneyasu, Hiroshi Kamisoyama

Affiliations

  1. Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.

PMID: 32055224 PMCID: PMC7005399 DOI: 10.2141/jpsa.0180127

Abstract

Insulin-like growth factor-1 (IGF-1) is a key regulator of muscle development and metabolism in chickens. Recently, we have demonstrated that intracerebroventricular administration of IGF-1 significantly decreased food intake in broiler chicks. However, the molecular mechanisms underlying the IGF-1-induced anorexia and the anorexigenic effect of IGF-1 in different strains of commercial chicks have not been investigated. Neuropeptide Y (NPY, a hypothalamic orexigenic neuropeptide), agouti-related protein (AgRP, a hypothalamic orexigenic neuropeptide), and proopiomelanocortin (POMC, the precursor of hypothalamic anorexigenic neuropeptides) play important roles in the regulation of food intake in both mammals and chickens. Evidence shows that several cell signaling pathways in the hypothalamus are involved in regulating the feeding behavior of mammals. In the present study, we first investigated the effects of IGF-1 on the expression of appetite-regulating neuropeptides and phosphorylation of signaling molecules in the hypothalamus of broiler chicks. Intracerebroventricular administration of IGF-1 significantly increased the mRNA levels of POMC, whereas the mRNA levels of NPY and AgRP were not significantly altered. IGF-1 also significantly induced the phosphorylation of v-Akt murine thymoma viral oncogene homolog 1 (AKT) in the hypothalamus of chicks, but did not influence the phosphorylation of forkhead box O1, S6 protein, AMP-activated protein kinase, and extracellular signal-regulated kinase 1/2. We also compared the effect of IGF-1 on food intake in broiler chicks (a hyperphagic strain of chickens) and layer chicks. Results demonstrated that the threshold of IGF-1-induced anorexia in broiler chicks was higher than that in layer chicks. Our observations suggest that hypothalamic POMC and AKT may be involved in the IGF-1-induced anorexigenic pathway and that high threshold of IGF-1-induced anorexia in broiler chicks might be one of the causes of hyperphagia in broiler chicks. Overall, it appears that IGF-1 plays important roles in the central regulation of feeding behavior in chicks.

2019, Japan Poultry Science Association.

Keywords: appetite; brain; chick; feed intake; peptide

Conflict of interest statement

The authors declare no conflict of interest.

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