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Song JH, Kim KJ, Chei S, et al. Korean Red Ginseng and Korean black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress. J Ginseng Res. 2018;44(2):267-273doi: 10.1016/j.jgr.2018.12.005.
Song, J. H., Kim, K. J., Chei, S., Seo, Y. J., Lee, K., & Lee, B. Y. (2020). Korean Red Ginseng and Korean black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress. Journal of ginseng research, 44(2), 267-273. https://doi.org/10.1016/j.jgr.2018.12.005
Song, Ji-Hyeon, et al. "Korean Red Ginseng and Korean black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress." Journal of ginseng research vol. 44,2 (2020): 267-273. doi: https://doi.org/10.1016/j.jgr.2018.12.005
Song JH, Kim KJ, Chei S, Seo YJ, Lee K, Lee BY. Korean Red Ginseng and Korean black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress. J Ginseng Res. 2020 Mar;44(2):267-273. doi: 10.1016/j.jgr.2018.12.005. Epub 2018 Dec 16. PMID: 32148408; PMCID: PMC7031738.
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J Ginseng Res. 2020 Mar;44(2):267-273. doi: 10.1016/j.jgr.2018.12.005. Epub 2018 Dec 16.

Korean Red Ginseng and Korean black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress.

Journal of ginseng research

Ji-Hyeon Song, Kui-Jin Kim, Sungwoo Chei, Young-Jin Seo, Kippeum Lee, Boo-Yong Lee

Affiliations

  1. Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Republic of Korea.

PMID: 32148408 PMCID: PMC7031738 DOI: 10.1016/j.jgr.2018.12.005

Abstract

BACKGROUND: Continuous exposure to high temperatures can lead to heat stress. This stress response alters the expression of multiple genes and can contribute to the onset of various diseases. In particular, heat stress induces oxidative stress by increasing the production of reactive oxygen species. The liver is an essential organ that plays a variety of roles, such as detoxification and protein synthesis. Therefore, it is important to protect the liver from oxidative stress caused by heat stress. Korean ginseng has a variety of beneficial biological properties, and our previous studies showed that it provides an effective defense against heat stress.

METHODS: We investigated the ability of Korean Red Ginseng and Korean black ginseng extracts (JP5 and BG1) to protect against heat stress using a rat model. We then confirmed the active ingredients and mechanism of action using a cell-based model.

RESULTS: Heat stress significantly increased gene and protein expression of oxidative stress-related factors such as catalase and SOD2, but treatment with JP5 (Korean Red Ginseng extract) and BG1 (Korean black ginseng extract) abolished this response in both liver tissue and HepG2 cells. In addition, JP5 and BG1 inhibited the expression of inflammatory proteins such as p-NF-κB and tumor necrosis factor alpha-α. In particular, JP5 and BG1 decreased the expression of components of the NLRP3 inflammasome, a key inflammatory signaling factor. Thus, JP5 and BG1 inhibited both oxidative stress and inflammation.

CONCLUSIONS: JP5 and BG1 protect against oxidative stress and inflammation induced by heat stress and help maintain liver function by preventing liver damage.

© 2018 The Korean Society of Ginseng, Published by Elsevier Korea LLC.

Keywords: Heat stress; Inflammation; Korean ginseng extracts; Oxidative stress; Sprague–Dawley rats

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