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Helal M, Allen KJH, van Dijk B, et al. Radioimmunotherapy of Blastomycosis in a Mouse Model With a (1→3)-β-Glucans Targeting Antibody. Front Microbiol. 2020;11:147doi: 10.3389/fmicb.2020.00147.
Helal, M., Allen, K. J. H., van Dijk, B., Nosanchuk, J. D., Snead, E., & Dadachova, E. (2020). Radioimmunotherapy of Blastomycosis in a Mouse Model With a (1→3)-β-Glucans Targeting Antibody. Frontiers in microbiology, 11147. https://doi.org/10.3389/fmicb.2020.00147
Helal, Muath, et al. "Radioimmunotherapy of Blastomycosis in a Mouse Model With a (1→3)-β-Glucans Targeting Antibody." Frontiers in microbiology vol. 11 (2020): 147. doi: https://doi.org/10.3389/fmicb.2020.00147
Helal M, Allen KJH, van Dijk B, Nosanchuk JD, Snead E, Dadachova E. Radioimmunotherapy of Blastomycosis in a Mouse Model With a (1→3)-β-Glucans Targeting Antibody. Front Microbiol. 2020 Feb 07;11:147. doi: 10.3389/fmicb.2020.00147. eCollection 2020. PMID: 32117166; PMCID: PMC7019017.
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Front Microbiol. 2020 Feb 07;11:147. doi: 10.3389/fmicb.2020.00147. eCollection 2020.

Radioimmunotherapy of Blastomycosis in a Mouse Model With a (1→3)-β-Glucans Targeting Antibody.

Frontiers in microbiology

Muath Helal, Kevin J H Allen, Bruce van Dijk, Joshua D Nosanchuk, Elisabeth Snead, Ekaterina Dadachova

Affiliations

  1. College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.
  2. Department of Orthopedics, University Medical Center Utrecht, Utrecht, Netherlands.
  3. Department of Medicine, Albert Einstein College of Medicine, The Bronx, NY, United States.
  4. Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

PMID: 32117166 PMCID: PMC7019017 DOI: 10.3389/fmicb.2020.00147

Abstract

Invasive fungal infections (IFI) cause devastating morbidity and mortality, with the number of IFIs more than tripling since 1979. Our laboratories were the first to demonstrate that radiolabeled microorganism-specific monoclonal antibodies are highly effective for treatment of experimental fungal, bacterial and viral infections. Later we proposed to utilize surface expressed pan-antigens shared by major IFI-causing pathogens such as beta-glucans as RIT targets. Here we evaluated

Copyright © 2020 Helal, Allen, van Dijk, Nosanchuk, Snead and Dadachova.

Keywords: (1→3)-β-glucan; 213Bismuth; Blastomyces dermatitidis; mouse model; radioimmunotherapy

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