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Xu X, Dong HC, Yao Z, et al. Risk factors for postoperative sepsis in patients with gastrointestinal perforation. World J Clin Cases. 2020;8(4):670-678doi: 10.12998/wjcc.v8.i4.670.
Xu, X., Dong, H. C., Yao, Z., & Zhao, Y. Z. (2020). Risk factors for postoperative sepsis in patients with gastrointestinal perforation. World journal of clinical cases, 8(4), 670-678. https://doi.org/10.12998/wjcc.v8.i4.670
Xu, Xin, et al. "Risk factors for postoperative sepsis in patients with gastrointestinal perforation." World journal of clinical cases vol. 8,4 (2020): 670-678. doi: https://doi.org/10.12998/wjcc.v8.i4.670
Xu X, Dong HC, Yao Z, Zhao YZ. Risk factors for postoperative sepsis in patients with gastrointestinal perforation. World J Clin Cases. 2020 Feb 26;8(4):670-678. doi: 10.12998/wjcc.v8.i4.670. PMID: 32149051; PMCID: PMC7052561.
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World J Clin Cases. 2020 Feb 26;8(4):670-678. doi: 10.12998/wjcc.v8.i4.670.

Risk factors for postoperative sepsis in patients with gastrointestinal perforation.

World journal of clinical cases

Xin Xu, Hai-Chang Dong, Zheng Yao, Yun-Zhao Zhao

Affiliations

  1. Department of General Surgery, Jiangning Hospital, Nanjing 210002, Jiangsu Province, China.
  2. Department of General Surgery, Huaihe Hospital, Kaifeng 475000, Henan Province, China.
  3. Department of General Surgery, Jiangning Hospital, Nanjing 210002, Jiangsu Province, China. [email protected].

PMID: 32149051 PMCID: PMC7052561 DOI: 10.12998/wjcc.v8.i4.670

Abstract

BACKGROUND: Sepsis is fatal in patients with gastrointestinal perforation (GIP). However, few studies have focused on this issue.

AIM: To investigate the risk factors for postoperative sepsis in patients with GIP.

METHODS: This was a retrospective study performed at the Department of General Surgery in our treatment center. From January 2016 to December 2018, the medical records of patients with GIP who underwent emergency surgery were reviewed. Patients younger than 17 years or who did not undergo surgical treatment were excluded. The patients were divided into the postoperative sepsis group and the non-postoperative sepsis group. Clinical data for both groups were collected and compared, and the risk factors for postoperative sepsis were investigated. The institutional ethical committee of our hospital approved the study.

RESULTS: Two hundred twenty-six patients were admitted to our department with GIP. Fourteen patients were excluded: Four were under 17 years old, and 10 did not undergo emergency surgery due to high surgical risk and/or disagreement with the patients and their family members. Two hundred twelve patients were finally enrolled in the study; 161 were men, and 51 were women. The average age was 62.98 ± 15.65 years. Postoperative sepsis occurred in 48 cases. The prevalence of postoperative sepsis was 22.6% [95% confidence interval (CI): 17.0%-28.3%]. Twenty-eight patients (13.21%) died after emergency surgery. Multiple logistic regression analysis confirmed that the time interval from abdominal pain to emergency surgery [odds ratio (OR) = 1.021, 95%CI: 1.005-1.038,

CONCLUSION: The time interval from abdominal pain to surgery, colonic perforation, diameter of perforation, and the incidence of malignant tumor-related perforation were risk factors for postoperative sepsis in patients with GIP.

©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

Keywords: Gastrointestinal perforation; Postoperative period; Prevalence; Risk factor; Sepsis

Conflict of interest statement

Conflict-of-interest statement: The authors have nothing to disclose.

References

  1. World J Gastroenterol. 2017 Jun 28;23(24):4422-4427 - PubMed
  2. Intensive Care Med. 2007 Mar;33(3):435-43 - PubMed
  3. World J Surg. 2017 Aug;41(8):1961-1965 - PubMed
  4. Eur J Trauma Emerg Surg. 2018 Apr;44(2):251-257 - PubMed
  5. Am J Case Rep. 2017 Jan 20;18:72-75 - PubMed
  6. Ther Clin Risk Manag. 2015 Oct 05;11:1523-9 - PubMed
  7. Scand J Surg. 2004;93(3):204-8 - PubMed
  8. Ulus Cerrahi Derg. 2014 Oct 20;31(1):20-5 - PubMed
  9. J Gastroenterol Hepatol. 2007 Apr;22(4):565-70 - PubMed
  10. Arthritis Rheum. 2011 Feb;63(2):346-51 - PubMed
  11. Med Sci Monit. 2018 Jun 09;24:3888-3894 - PubMed
  12. Gastrointest Endosc. 2015 Oct;82(4):618-28.e5 - PubMed
  13. Br J Surg. 2017 Jul;104(8):959-961 - PubMed
  14. Arthritis Rheumatol. 2016 Nov;68(11):2612-2617 - PubMed
  15. JAMA. 2016 Feb 23;315(8):757-9 - PubMed
  16. Ann Rheum Dis. 2014 Jan;73(1):252-5 - PubMed
  17. Radiology. 2009 Aug;252(2):410-7 - PubMed
  18. Gastrointest Endosc. 2012 Jul;76(1):202-8 - PubMed
  19. Endoscopy. 2013 Oct;45(10):806-12 - PubMed
  20. Ann Surg. 1997 Jun;225(6):744-53; discussion 753-6 - PubMed
  21. JAMA Surg. 2015 Feb;150(2):177-8 - PubMed
  22. Eur J Gastroenterol Hepatol. 2005 Jan;17(1):121-4 - PubMed
  23. World J Gastroenterol. 2019 Feb 28;25(8):1024-1030 - PubMed

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