Display options
Cite
Parle E, Tio S, Behre A, et al. Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study. JBMR Plus. 2019;4(2):e10253doi: 10.1002/jbm4.10253.
Parle, E., Tio, S., Behre, A., Carey, J. J., Murphy, C. G., O'Brien, T. F., Curtin, W. A., Kearns, S. R., McCabe, J. P., Coleman, C. M., Vaughan, T. J., & McNamara, L. M. (2020). Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study. JBMR plus, 4(2), e10253. https://doi.org/10.1002/jbm4.10253
Parle, Eoin, et al. "Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study." JBMR plus vol. 4,2 (2020): e10253. doi: https://doi.org/10.1002/jbm4.10253
Parle E, Tio S, Behre A, Carey JJ, Murphy CG, O'Brien TF, Curtin WA, Kearns SR, McCabe JP, Coleman CM, Vaughan TJ, McNamara LM. Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study. JBMR Plus. 2019 Dec 11;4(2):e10253. doi: 10.1002/jbm4.10253. eCollection 2020 Feb. PMID: 32149268; PMCID: PMC7017882.
Copy Download .nbib Format: NLM
Share it on

JBMR Plus. 2019 Dec 11;4(2):e10253. doi: 10.1002/jbm4.10253. eCollection 2020 Feb.

Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study.

JBMR plus

Eoin Parle, Sherdya Tio, Annie Behre, John J Carey, Colin G Murphy, Timothy F O'Brien, William A Curtin, Stephen R Kearns, John P McCabe, Cynthia M Coleman, Ted J Vaughan, Laoise M McNamara

Affiliations

  1. Department of Biomedical Engineering National University of Ireland Galway Galway Ireland.
  2. Department of Bioengineering Lehigh University Bethlehem PA USA.
  3. Department of Rheumatology Galway University Hospitals Galway Ireland.
  4. Department of Orthopaedics Galway University Hospitals Galway Ireland.
  5. Department of Endocrinology Galway University Hospitals Galway Ireland.

PMID: 32149268 PMCID: PMC7017882 DOI: 10.1002/jbm4.10253

Abstract

Osteoporosis is associated with systemic bone loss, leading to a significant deterioration of bone microarchitecture and an increased fracture risk. Although recent studies have shown that the distribution of bone mineral becomes more heterogeneous because of estrogen deficiency in animal models of osteoporosis, it is not known whether osteoporosis alters mineral distribution in human bone. Type 2 diabetes mellitus (T2DM) can also increase bone fracture risk and is associated with impaired bone cell function, compromised collagen structure, and reduced mechanical properties. However, it is not known whether alterations in mineral distribution arise in diabetic (DB) patients' bone. In this study, we quantify mineral content distribution and tissue microarchitecture (by μCT) and mechanical properties (by compression testing) of cancellous bone from femoral heads of osteoporotic (OP;

© 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

Keywords: DIABETES; MECHANICAL PROPERTIES; MICROARCHITECTURE; MINERAL HETEROGENEITY; OSTEOARTHRITIS; OSTEOPOROSIS

References

  1. Bone. 2004 Jan;34(1):163-9 - PubMed
  2. Biophys J. 2015 Apr 7;108(7):1587-1598 - PubMed
  3. J Bone Miner Res. 1997 Apr;12(4):641-51 - PubMed
  4. J Bone Miner Res. 2015 May;30(5):786-95 - PubMed
  5. J Bone Joint Surg Br. 1981 Aug;63-B(2):233-8 - PubMed
  6. J Bone Miner Res. 2014 Feb;29(2):440-9 - PubMed
  7. Acta Orthop. 2013 Oct;84(5):453-9 - PubMed
  8. J Bone Miner Res. 2019 Jul;34(7):1191-1206 - PubMed
  9. World Health Organ Tech Rep Ser. 1994;843:1-129 - PubMed
  10. Lab Invest. 2013 Nov;93(11):1170-83 - PubMed
  11. JAMA. 2011 Jun 1;305(21):2184-92 - PubMed
  12. PLoS One. 2016 May 03;11(5):e0154700 - PubMed
  13. Bone. 2017 Jun;99:53-61 - PubMed
  14. Osteoporos Int. 2005 Mar;16(3):229-38 - PubMed
  15. Osteoporos Int. 2009 Jun;20(6):1023-6 - PubMed
  16. Bone. 1998 Mar;22(3):241-50 - PubMed
  17. J Bone Miner Res. 2006 Jul;21(7):1106-12 - PubMed
  18. Metabolism. 2013 Oct;62(10):1401-5 - PubMed
  19. Injury. 2016 Jun;47 Suppl 2:S11-20 - PubMed
  20. J Mech Behav Biomed Mater. 2014 Jan;29:161-70 - PubMed
  21. Bone. 2012 Mar;50(3):688-94 - PubMed
  22. Curr Osteoporos Rep. 2014 Sep;12(3):338-50 - PubMed
  23. Osteoporos Int. 2005 Dec;16(12):1713-20 - PubMed
  24. J Clin Endocrinol Metab. 2010 Nov;95(11):5045-55 - PubMed
  25. J R Soc Interface. 2012 Oct 7;9(75):2735-44 - PubMed
  26. Osteoarthritis Cartilage. 2011 Feb;19(2):180-5 - PubMed
  27. Calcif Tissue Int. 2015 Sep;97(3):262-80 - PubMed
  28. Philos Trans R Soc Lond B Biol Sci. 1984 Feb 13;304(1121):509-18 - PubMed
  29. J Bone Miner Res. 2013 Feb;28(2):313-24 - PubMed
  30. Osteoporos Int. 2012 Feb;23(2):635-41 - PubMed
  31. Eur Cell Mater. 2011 May 15;21:396-406 - PubMed
  32. Lipids. 2014 Oct;49(10):975-86 - PubMed
  33. J R Soc Interface. 2010 Mar 6;7(44):353-72 - PubMed
  34. Bone. 2006 Feb;38(2 Suppl 1):S4-9 - PubMed
  35. Curr Osteoporos Rep. 2014 Jun;12(2):181-8 - PubMed
  36. J Biomech. 2008;41(7):1427-35 - PubMed
  37. J Bone Miner Res. 2001 Mar;16(3):457-65 - PubMed
  38. J Orthop Res. 1988;6(3):317-23 - PubMed
  39. J Craniofac Surg. 2012 Sep;23(5):1502-6 - PubMed
  40. J Bone Miner Res. 2014 Apr;29(4):787-95 - PubMed
  41. Calcif Tissue Int. 1984;36 Suppl 1:S37-45 - PubMed
  42. Am J Med. 1987 Jan 26;82(1B):68-72 - PubMed
  43. J Bone Miner Res. 2010 Jul;25(7):1468-86 - PubMed
  44. J Biomech. 2003 Oct;36(10):1461-7 - PubMed
  45. J Bone Miner Res. 2014;29(5):1025-40 - PubMed
  46. Osteoporos Int. 2007 Apr;18(4):427-44 - PubMed
  47. Arthritis Care Res (Hoboken). 2012 Jan;64(1):83-91 - PubMed
  48. Bone. 2004 May;34(5):783-9 - PubMed
  49. Bone. 2013 May;54(1):76-82 - PubMed
  50. Med Eng Phys. 1997 Dec;19(8):729-37 - PubMed
  51. Bone. 2009 Apr;44(4):648-55 - PubMed
  52. Bone. 2011 Aug;49(2):174-83 - PubMed
  53. Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1220-8 - PubMed
  54. J Bone Miner Res. 2012 Dec;27(12):2551-61 - PubMed
  55. Bone. 2006 Aug;39(2):392-400 - PubMed
  56. J Bone Miner Res. 2018 Jan;33(1):54-62 - PubMed
  57. Bone. 2018 Sep;114:32-39 - PubMed
  58. Bone. 2009 Dec;45(6):1034-43 - PubMed
  59. World J Diabetes. 2015 Jun 10;6(5):673-8 - PubMed
  60. J Mol Endocrinol. 2014 Jan 09;52(1):67-76 - PubMed
  61. J Bone Miner Res. 2001 Feb;16(2):214-20 - PubMed
  62. Osteoporos Int. 2010 Feb;21(2):195-214 - PubMed
  63. J Bone Miner Res. 2002 Mar;17(3):528-33 - PubMed

Publication Types