Display options
Cite
Chung HY, Wickel J, Brunkhorst FM, et al. Sepsis-Associated Encephalopathy: From Delirium to Dementia?. J Clin Med. 2020;9(3)doi: 10.3390/jcm9030703.
Chung, H. Y., Wickel, J., Brunkhorst, F. M., & Geis, C. (2020). Sepsis-Associated Encephalopathy: From Delirium to Dementia?. Journal of clinical medicine, 9(3), . https://doi.org/10.3390/jcm9030703
Chung, Ha-Yeun, et al. "Sepsis-Associated Encephalopathy: From Delirium to Dementia?." Journal of clinical medicine vol. 9,3 (2020). doi: https://doi.org/10.3390/jcm9030703
Chung HY, Wickel J, Brunkhorst FM, Geis C. Sepsis-Associated Encephalopathy: From Delirium to Dementia?. J Clin Med. 2020 Mar 05;9(3). doi: 10.3390/jcm9030703. PMID: 32150970; PMCID: PMC7141293.
Copy Download .nbib Format: NLM
Share it on

J Clin Med. 2020 Mar 05;9(3). doi: 10.3390/jcm9030703.

Sepsis-Associated Encephalopathy: From Delirium to Dementia?.

Journal of clinical medicine

Ha-Yeun Chung, Jonathan Wickel, Frank M Brunkhorst, Christian Geis

Affiliations

  1. Section Translational Neuroimmunology, Department of Neurology, Jena University Hospital, 07747 Jena, Germany.
  2. Center for Sepsis Control and Care, Jena University Hospital, Jena 07747, Germany.
  3. Center for Clinical Studies and Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07747 Jena, Germany.

PMID: 32150970 PMCID: PMC7141293 DOI: 10.3390/jcm9030703

Abstract

Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving patients suffer from severe and long-term cognitive deficits compromising their daily quality of life and placing an immense burden on primary caregivers. Due to a growing number of sepsis survivors, these long-lasting deficits are increasingly relevant. Despite the high incidence and clinical relevance, the pathomechanisms of acute and chronic stages in sepsis-associated encephalopathy are only incompletely understood, and no specific therapeutic options are yet available. Here, we review the emergence of sepsis-associated encephalopathy from initial clinical presentation to long-term cognitive impairment in sepsis survivors and summarize pathomechanisms potentially contributing to the development of sepsis-associated encephalopathy.

Keywords: SAE; brain dysfunction; cognitive deficits; delirium; dementia; encephalopathy; long-term sequelae; pathophysiology; sepsis

References

  1. Neurochem Res. 2020 Jan;45(1):83-99 - PubMed
  2. Immun Ageing. 2019 Jul 30;16:18 - PubMed
  3. Neurology. 2017 May 9;88(19):1788-1794 - PubMed
  4. Crit Care. 2008;12(3):R63 - PubMed
  5. J Clin Neurophysiol. 1992 Jan;9(1):145-52 - PubMed
  6. J Crit Care. 2016 Dec;36:18-23 - PubMed
  7. Ann Intern Med. 1990 Dec 15;113(12):941-8 - PubMed
  8. Am J Respir Crit Care Med. 2010 Jul 15;182(2):183-91 - PubMed
  9. JAMA. 2010 Oct 27;304(16):1787-94 - PubMed
  10. Crit Care Med. 2014 Feb;42(2):e114-22 - PubMed
  11. JAMA. 2017 Apr 4;317(13):1321-1328 - PubMed
  12. Lancet Respir Med. 2015 Jan;3(1):61-9 - PubMed
  13. Handb Clin Neurol. 2014;119:383-93 - PubMed
  14. Clin Chest Med. 2016 Jun;37(2):165-79 - PubMed
  15. Am J Respir Crit Care Med. 2014 Jul 1;190(1):62-9 - PubMed
  16. Crit Care. 2006;10(5):R134 - PubMed
  17. Nat Rev Dis Primers. 2016 Jun 30;2:16045 - PubMed
  18. Neurobiol Dis. 2010 Jan;37(1):13-25 - PubMed
  19. Mayo Clin Proc. 2018 Jan;93(1):68-82 - PubMed
  20. Crit Care Med. 2006 Jul;34(7):1967-74 - PubMed
  21. Physiol Rev. 2018 Jan 1;98(1):239-389 - PubMed
  22. Intensive Care Med. 2014 Feb;40(2):228-34 - PubMed
  23. J Neurosci. 2011 Mar 16;31(11):4154-65 - PubMed
  24. J Gen Intern Med. 2001 Nov;16(11):770-8 - PubMed
  25. Crit Care. 2010;14(5):199 - PubMed
  26. Crit Care Med. 2010 Feb;38(2):409-18 - PubMed
  27. Crit Care Med. 2013 Jan;41(1):263-306 - PubMed
  28. PLoS One. 2019 Jan 24;14(1):e0211184 - PubMed
  29. Intensive Care Med. 2014 Mar;40(3):370-9 - PubMed
  30. Ann Intern Med. 2019 Sep 3;: - PubMed
  31. Chin Med J (Engl). 2012 Mar;125(5):828-31 - PubMed
  32. Lancet. 2009 May 30;373(9678):1874-82 - PubMed
  33. J Neuroimmunol. 2017 Feb 15;303:90-98 - PubMed
  34. Intensive Care Med. 2017 Aug;43(8):1075-1084 - PubMed
  35. Neurology. 2015 Jun 2;84(22):2247-57 - PubMed
  36. JAMA. 2014 Apr 2;311(13):1308-16 - PubMed
  37. J Cent Nerv Syst Dis. 2019 Apr 09;11:1179573519840652 - PubMed
  38. Cell. 2016 Jan 14;164(1-2):183-196 - PubMed
  39. JAMA. 2010 Oct 27;304(16):1833-4 - PubMed
  40. Brain Pathol. 2004 Jan;14(1):21-33 - PubMed
  41. AJNR Am J Neuroradiol. 2006 Nov-Dec;27(10):2179-90 - PubMed
  42. Am J Respir Crit Care Med. 2013 Sep 1;188(5):567-76 - PubMed
  43. J Intensive Care Med. 2018 Feb;33(2):63-73 - PubMed
  44. Neuron. 2013 Jan 9;77(1):10-8 - PubMed
  45. Intensive Care Med. 2001 May;27(5):859-64 - PubMed
  46. PLoS One. 2014 Nov 14;9(11):e110935 - PubMed
  47. Shock. 2018 Oct;50(4):377-380 - PubMed
  48. Crit Care. 2013 Sep 18;17(5):R204 - PubMed
  49. Crit Care Med. 2010 Jul;38(7):1513-20 - PubMed
  50. Hepatology. 2014 Aug;60(2):715-35 - PubMed
  51. Gen Hosp Psychiatry. 2001 Mar-Apr;23(2):90-6 - PubMed
  52. PLoS One. 2015 Oct 08;10(10):e0139969 - PubMed
  53. Nat Rev Neurol. 2013 Oct;9(10):551-61 - PubMed
  54. Crit Care Med. 2014 Aug;42(8):1899-909 - PubMed
  55. Lancet Respir Med. 2018 Mar;6(3):213-222 - PubMed
  56. Crit Care Med. 2009 Oct;37(10 Suppl):S331-6 - PubMed
  57. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1712-9 - PubMed
  58. Crit Care. 2017 Mar 21;21(1):65 - PubMed
  59. JAMA. 1996 Feb 14;275(6):470-3 - PubMed
  60. JAMA Psychiatry. 2016 Sep 1;73(9):912-9 - PubMed
  61. Neuropathol Appl Neurobiol. 2019 Apr;45(3):278-290 - PubMed
  62. JCI Insight. 2018 May 3;3(9): - PubMed
  63. Neurocrit Care. 2020 Feb;32(1):121-130 - PubMed
  64. N Engl J Med. 2013 Oct 3;369(14):1306-16 - PubMed
  65. J Intensive Care. 2017 Feb 17;5:18 - PubMed
  66. Ann Am Thorac Soc. 2017 Feb;14(2):230-237 - PubMed
  67. Life Sci. 2019 Oct 15;235:116822 - PubMed
  68. Clin Interv Aging. 2009;4:225-33 - PubMed
  69. Intensive Care Med. 2002 Mar;28(3):293-8 - PubMed
  70. Am J Respir Crit Care Med. 2016 Oct 1;194(7):782-783 - PubMed
  71. Can J Neurol Sci. 1985 Nov;12(4):303-7 - PubMed
  72. J Immunol. 2019 Dec 1;203(11):2979-2989 - PubMed
  73. Lancet. 2010 Feb 27;375(9716):773-5 - PubMed
  74. Chest. 2018 Apr;153(4):805-815 - PubMed
  75. Crit Care Med. 2001 Jul;29(7):1370-9 - PubMed
  76. Nat Rev Immunol. 2018 Apr;18(4):225-242 - PubMed
  77. Neurology. 2017 Feb 28;88(9):826-831 - PubMed
  78. Crit Care Med. 2002 Oct;30(10):2371-5 - PubMed
  79. Ann Intern Med. 2014 Oct 21;161(8):554-61 - PubMed
  80. Crit Care Med. 2017 Oct;45(10):e1075-e1082 - PubMed
  81. Age Ageing. 2014 Jul;43(4):496-502 - PubMed
  82. Crit Care Med. 2015 Jun;43(6):1213-22 - PubMed
  83. J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):62-9 - PubMed
  84. Lancet. 2003 Nov 29;362(9398):1799-805 - PubMed
  85. Crit Care. 2014 Dec 08;18(6):674 - PubMed
  86. Crit Care. 2018 Dec 4;22(1):327 - PubMed
  87. J Pain Symptom Manage. 2005 Apr;29(4):368-75 - PubMed
  88. Exp Neurol. 2007 Apr;204(2):733-40 - PubMed
  89. Lancet. 2010 Nov 27;376(9755):1829-37 - PubMed
  90. Front Immunol. 2017 Jun 16;8:597 - PubMed
  91. Crit Care Med. 1990 Aug;18(8):801-6 - PubMed
  92. Crit Care. 2010;14(2):R38 - PubMed
  93. Am J Respir Crit Care Med. 2016 Feb 1;193(3):259-72 - PubMed
  94. Ann Intern Med. 2014 Apr 15;160(8):526-533 - PubMed
  95. Neuron. 2017 Nov 1;96(3):697-708 - PubMed
  96. Ann Am Thorac Soc. 2013 Aug;10(4):315-23 - PubMed
  97. J Neuroinflammation. 2007 Jan 15;4:4 - PubMed
  98. N Engl J Med. 2018 Dec 27;379(26):2506-2516 - PubMed
  99. Crit Care Med. 2012 Jul;40(7):2022-32 - PubMed
  100. Nat Rev Neurol. 2012 Oct;8(10):557-66 - PubMed

Publication Types

Grant support