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Hosseinzadeh Zoroufchi B, Doustmohammadi H, Mokhtari T, et al. Benzodiazepines related sexual dysfunctions: A critical review on pharmacology and mechanism of action. Rev Int Androl. 2020;19(1):62-68doi: 10.1016/j.androl.2019.08.003.
Hosseinzadeh Zoroufchi, B., Doustmohammadi, H., Mokhtari, T., & Abdollahpour, A. (2021). Benzodiazepines related sexual dysfunctions: A critical review on pharmacology and mechanism of action. Revista internacional de andrologia, 19(1), 62-68. https://doi.org/10.1016/j.androl.2019.08.003
Hosseinzadeh Zoroufchi, Babak, et al. "Benzodiazepines related sexual dysfunctions: A critical review on pharmacology and mechanism of action." Revista internacional de andrologia vol. 19,1 (2021): 62-68. doi: https://doi.org/10.1016/j.androl.2019.08.003
Hosseinzadeh Zoroufchi B, Doustmohammadi H, Mokhtari T, Abdollahpour A. Benzodiazepines related sexual dysfunctions: A critical review on pharmacology and mechanism of action. Rev Int Androl. 2021 Jan-Mar;19(1):62-68. doi: 10.1016/j.androl.2019.08.003. Epub 2020 Feb 13. PMID: 32063496.
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Rev Int Androl. 2021 Jan-Mar;19(1):62-68. doi: 10.1016/j.androl.2019.08.003. Epub 2020 Feb 13.

Benzodiazepines related sexual dysfunctions: A critical review on pharmacology and mechanism of action.

Revista internacional de andrologia

Babak Hosseinzadeh Zoroufchi, Hoda Doustmohammadi, Tahmineh Mokhtari, Abolfazl Abdollahpour

Affiliations

  1. Department of Anesthesiology, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran.
  2. Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
  3. Legal Medicine research centre, Legal Medicine organisation, Tehran, Iran.
  4. Department of Anesthesiology, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran. Electronic address: [email protected].

PMID: 32063496 DOI: 10.1016/j.androl.2019.08.003

Abstract

INTRODUCTION: Normal sexual functioning of both men and women, being a very complex process, is affected by numerous issues besides aging. Many factors affect the sexual function and lifestyle of the young population. In this article, we tried to review the literature to update the knowledge on benzodiazepine-related (BZD) sexual dysfunction (SD) and involved mechanisms of actions based on animal and human studies.

METHODS: Different standard websites such as PubMed were used to review the literature and keywords including benzodiazepines, sexual dysfunction, gammaaminobutyric acid A (GABAA) receptor and erectile dysfunction were used.

RESULTS: SD is one of the most common disorders in males and females which has recently been demonstrated to be associated with psychotropic medications such as antihypertensive agents, tranquilizers, antihistamines, appetite suppressants, antidepressants and anxiolytics. BZDs are among the most common psychotropic agents worldwide. SD including decreased libido, erectile dysfunction (ED) and other undesired sexual urges were observed in the patients receiving BZDs.

DISCUSSION: The mechanisms of action of BZDs to induce SD mainly relate to enhanced GABAA receptor function which reduces penile erection.

Copyright © 2019 Asociación Española de Andrología, Medicina Sexual y Reproductiva. Publicado por Elsevier España, S.L.U. All rights reserved.

Keywords: Benzodiacepinas; Benzodiazepines; Disfunciones sexuales; Disfunción eréctil; Erectile dysfunction; Gammaaminobutyric acid A; Sexual dysfunction; Ácido gamma-aminobutírico A

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