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Chen CH, Lin CL, Kao CH. Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones. Cancers (Basel). 2020;12(3)doi: 10.3390/cancers12030544.
Chen, C. H., Lin, C. L., & Kao, C. H. (2020). Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones. Cancers, 12(3), . https://doi.org/10.3390/cancers12030544
Chen, Chien-Hua, et al. "Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones." Cancers vol. 12,3 (2020). doi: https://doi.org/10.3390/cancers12030544
Chen CH, Lin CL, Kao CH. Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones. Cancers (Basel). 2020 Feb 27;12(3). doi: 10.3390/cancers12030544. PMID: 32120816; PMCID: PMC7139917.
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Cancers (Basel). 2020 Feb 27;12(3). doi: 10.3390/cancers12030544.

Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones.

Cancers

Chien-Hua Chen, Cheng-Li Lin, Chia-Hung Kao

Affiliations

  1. Digestive Disease Center, Changbing Show-Chwan Memorial Hospital, Lukang Township, Changhua County 500, Taiwan.
  2. Digestive Disease Center, Show-Chwan Memorial Hospital, Changhua 500, Taiwan.
  3. Department of Food Science and Technology, Hungkuang University, Taichung 433, Taiwan.
  4. Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan.
  5. College of Medicine, China Medical University, Taichung 404, Taiwan.
  6. Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan.
  7. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 404, Taiwan.
  8. Department of Bioinformatics and Medical Engineering, Asia University, Taichung 404, Taiwan.

PMID: 32120816 PMCID: PMC7139917 DOI: 10.3390/cancers12030544

Abstract

OBJECTIVES: To assess the association of cholecystectomy with the risk of prostate cancer in patients with gallstones.

METHODS: This nationwide population-based cohort study was conducted by retrieving the Longitudinal Health Insurance Research Database (LHID2000) for inpatient claims in the Taiwan National Health Insurance (NHI) program. The study cohort consisted of 72,606 men aged 20 years with gallstones undergoing cholecystectomy between 2000 and 2010. The control cohort consisted of the men with gallstones, but without cholecystectomy, by 1:1 propensity score matching with the study cohort based on age, sex, urbanization, occupation, comorbidities, and the index date. We compared the hazard ratio of prostate cancer between both of the cohorts.

RESULTS: The incidence of prostate cancer was 0.76/1000 person-years for the non-cholecystectomy cohort and 1.28/1000 person-years for the cholecystectomy cohort [aHR (adjusted hazard ratio) = 1.67, 95% confidence interval (CI = 1.45-1.92), respectively (p < 0.001). When compared with the non-cholecystectomy cohort, the hazard ratio of prostate cancer for the cholecystectomy cohort was 1.49-fold greater (95% CI = 1.04-2.11) for follow-up ≤ 1 year, 1.52-fold greater (95% CI = 1.24-1.86) for follow-up 1-5 years, and 1.99-fold greater (95% CI = 1.56-2.53) for follow-up > 5 years, respectively.

CONCLUSIONS: Cholecystectomy is associated with an increased hazard ratio of prostate cancer in gallstones patients, and the risk increases with an incremental period of follow-up. This observational study cannot ascertain the detrimental mechanisms of cholecystectomy for the development of prostate cancer, and cholecystectomy is not recommended for the prevention of prostate cancer based on our study.

Keywords: Cholecystectomy; Gallstones; Prostate cancer

Conflict of interest statement

The authors declare no conflict of interest.

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