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Musat G, Evsei A, Calina D, et al. Rare amyloidoma of the tongue base: A case report and review of the literature. Mol Clin Oncol. 2020;12(3):258-262doi: 10.3892/mco.2020.1972.
Musat, G., Evsei, A., Calina, D., Docea, A. O., Doukas, S. G., Vageli, D. P., Nepka, C., Spandidos, D. A., & Mitroi, M. (2020). Rare amyloidoma of the tongue base: A case report and review of the literature. Molecular and clinical oncology, 12(3), 258-262. https://doi.org/10.3892/mco.2020.1972
Musat, Gabriela, et al. "Rare amyloidoma of the tongue base: A case report and review of the literature." Molecular and clinical oncology vol. 12,3 (2020): 258-262. doi: https://doi.org/10.3892/mco.2020.1972
Musat G, Evsei A, Calina D, Docea AO, Doukas SG, Vageli DP, Nepka C, Spandidos DA, Mitroi M. Rare amyloidoma of the tongue base: A case report and review of the literature. Mol Clin Oncol. 2020 Mar;12(3):258-262. doi: 10.3892/mco.2020.1972. Epub 2020 Jan 09. PMID: 32064103; PMCID: PMC7016517.
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Mol Clin Oncol. 2020 Mar;12(3):258-262. doi: 10.3892/mco.2020.1972. Epub 2020 Jan 09.

Rare amyloidoma of the tongue base: A case report and review of the literature.

Molecular and clinical oncology

Gabriela Musat, Anca Evsei, Daniela Calina, Anca Oana Docea, Sotirios G Doukas, Dimitra P Vageli, Charitini Nepka, Demetrios A Spandidos, Mihaela Mitroi

Affiliations

  1. Department of Otorhinolaryngology, University of Medicine and Pharmacy 'Carol Davila', 050474 Bucharest, Romania.
  2. Laboratory of Anatomy-Histology, 'Saint Mary' Clinic Hospital, 011172 Bucharest, Romania.
  3. Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  4. Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  5. Department of Internal Medicine, Saint Peter's University Hospital, New Brunswick, NJ 08901, USA.
  6. Department of Forensic Sciences and Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
  7. Department of Surgery, The Yale Larynx Laboratory, New Haven, CT 06510, USA.
  8. Department of Cytopathology, University Hospital of Larissa, 41110 Larissa, Greece.
  9. Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
  10. Department of Otorhinolaryngology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

PMID: 32064103 PMCID: PMC7016517 DOI: 10.3892/mco.2020.1972

Abstract

Localized amyloidosis is a rare condition characterized by the deposition of misfolding protein in a tissue, without other systemic manifestations. Only a small number of cases of localized amyloidosis of the tongue have been reported to date, in contrast to systemic amyloidosis, in which localization on the tongue is common. This study presents a rare case of localized amyloidosis of the tongue (amyloidoma) and provides a summary of the known literature of localized amyloidosis. This study describes the case of a 36-year-old female who presented with a swelling of the tongue base. The diagnosis of amyloidoma was made based on the findings of the physical examination, head and neck MRI findings and the histopathological examination with Congo red stain under polarized light. The histopathological diagnosis was as follows: Localized lambda light-chain amyloidosis. A thorough physical examination was performed by the ENT and Hematology/Oncology departments, without revealing signs of systemic disease. A series of hematological and imaging tests were also performed to verify that there was no sign of systemic involvement. The patient declined surgical excision and the 2-year follow-up did not reveal any changes in tumor dimension. Although the etiology of localized amyloidosis is yet not clear, the prolonged reaction of tissue plasma cells to environmental antigens may be a causative factor for the initiation of the neoplastic process.

Copyright: © Musat et al.

Keywords: amyloidoma; biopsy; immunohistochemistry testing; microscopic examination; rare condition; tongue

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