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Piron S, De Man K, Schelfhout V, et al. Optimization of PET protocol and interrater reliability of . EJNMMI Res. 2020;10(1):14doi: 10.1186/s13550-020-0593-7.
Piron, S., De Man, K., Schelfhout, V., Van Laeken, N., Kersemans, K., Achten, E., De Vos, F., & Ost, P. (2020). Optimization of PET protocol and interrater reliability of . EJNMMI research, 10(1), 14. https://doi.org/10.1186/s13550-020-0593-7
Piron, Sarah, et al. "Optimization of PET protocol and interrater reliability of ." EJNMMI research vol. 10,1 (2020): 14. doi: https://doi.org/10.1186/s13550-020-0593-7
Piron S, De Man K, Schelfhout V, Van Laeken N, Kersemans K, Achten E, De Vos F, Ost P. Optimization of PET protocol and interrater reliability of . EJNMMI Res. 2020 Feb 24;10(1):14. doi: 10.1186/s13550-020-0593-7. PMID: 32095919; PMCID: PMC7040121.
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EJNMMI Res. 2020 Feb 24;10(1):14. doi: 10.1186/s13550-020-0593-7.

Optimization of PET protocol and interrater reliability of .

EJNMMI research

Sarah Piron, Kathia De Man, Vanessa Schelfhout, Nick Van Laeken, Ken Kersemans, Eric Achten, Filip De Vos, Piet Ost

Affiliations

  1. Laboratory of Radiopharmacy, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium. [email protected].
  2. Department Nuclear Medicine, Ghent University Hospital, Ghent, Belgium.
  3. Laboratory of Radiopharmacy, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
  4. Department Radiation Oncology, Ghent University Hospital, Ghent, Belgium.

PMID: 32095919 PMCID: PMC7040121 DOI: 10.1186/s13550-020-0593-7

Abstract

BACKGROUND: Several scan parameters for PET imaging with

RESULTS: The 4 MBq/kg group received for all reconstructed images (60 min p.i., 1.5 and 3 min/bed position and 180 min p.i., 1.5 and 3 min/bed position) the highest median image quality score compared to the 2 MBq/kg group (p values < 0.01). When comparing all reconstructed images, the highest image quality score was given to images at 60 min p.i., 3 min/bed position for both dosage groups (score 5 and 6 for 2 and 4 MBq/kg, respectively). The addition of furosemide administration decreased the interference score with one point (p = 0.01106) and facilitated the evaluation of lesions in proximity to the ureters. The interrater reliability for the comparison of each lesion separately after more than 40

CONCLUSION: Although the results indicate an administered activity of 4.0 ± 0.4 MBq/kg, preference will be given to 2.0 ± 0.2 MBq/kg due to the small difference in absolute score (max 1 point) and the ALARA principle. For evaluation of lesions in proximity to the ureters, the co-administration of a diuretic can be useful. The increase of the κ value from 0.78 to 0.94 suggests a learning curve in the interpretation of

TRIAL REGISTRATION: Clinicaltrials.gov, NCT03573011. Retrospectively registered 28 June 2018.

Keywords: 18F-PSMA-11; Acquisition time; Interrater reliability; PET/CT; PSMA; Prostate cancer; Randomized clinical trial; Scan protocol

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