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Suehiro KI, Suto A, Suga K, et al. Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells. Cell Mol Immunol. 2020;18(7):1729-1738doi: 10.1038/s41423-020-0384-0.
Suehiro, K. I., Suto, A., Suga, K., Furuya, H., Iwata, A., Iwamoto, T., Tanaka, S., Kageyama, T., Suzuki, K., Hirose, K., Lefebvre, V., & Nakajima, H. (2021). Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells. Cellular & molecular immunology, 18(7), 1729-1738. https://doi.org/10.1038/s41423-020-0384-0
Suehiro, Ken-Ichi, et al. "Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells." Cellular & molecular immunology vol. 18,7 (2021): 1729-1738. doi: https://doi.org/10.1038/s41423-020-0384-0
Suehiro KI, Suto A, Suga K, Furuya H, Iwata A, Iwamoto T, Tanaka S, Kageyama T, Suzuki K, Hirose K, Lefebvre V, Nakajima H. Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells. Cell Mol Immunol. 2021 Jul;18(7):1729-1738. doi: 10.1038/s41423-020-0384-0. Epub 2020 Mar 09. PMID: 32152552; PMCID: PMC8245422.
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Cell Mol Immunol. 2021 Jul;18(7):1729-1738. doi: 10.1038/s41423-020-0384-0. Epub 2020 Mar 09.

Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells.

Cellular & molecular immunology

Ken-Ichi Suehiro, Akira Suto, Kensuke Suga, Hiroki Furuya, Arifumi Iwata, Taro Iwamoto, Shigeru Tanaka, Takahiro Kageyama, Kotaro Suzuki, Koichi Hirose, Véronique Lefebvre, Hiroshi Nakajima

Affiliations

  1. Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba, Japan.
  2. Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba, Japan. [email protected].
  3. Institute for Global Prominent Research, Chiba University, Chiba, Japan. [email protected].
  4. Department of Surgery/Division of Orthopedic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  5. Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba, Japan. [email protected].

PMID: 32152552 PMCID: PMC8245422 DOI: 10.1038/s41423-020-0384-0

Abstract

Allergic asthma that is caused by inhalation of house dust mites (HDMs) is mainly mediated by Th2 cells. Recently, the roles of Sox (SRY-related high-mobility-group (HMG)-box) family members in various immune responses have been investigated. However, the roles of Sox12, a member of the SoxC group, in Th2 cell differentiation and allergic airway inflammation, remain unknown. We showed that Sox12 mRNA was significantly increased during Th2 cell differentiation. In vivo, HDM-induced eosinophil infiltration into the lung and Th2 cell differentiation were exacerbated in Sox12

Keywords: Asthma; GATA3; Sox12; Th2; ubiquitination

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