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Hansen SL, Ritterband-Rosenbaum A, Voigt CB, et al. Supplementation of docosahexaenoic acid (DHA), vitamin D. BMC Nutr. 2017;3:37doi: 10.1186/s40795-017-0155-1.
Hansen, S. L., Ritterband-Rosenbaum, A., Voigt, C. B., Hellgren, L. I., Sørensen, A. M., Jacobsen, C., Greve, L. Z., Jørgensen, K. D., Bilde, P. E., Kiens, B., & Nielsen, J. B. (2017). Supplementation of docosahexaenoic acid (DHA), vitamin D. BMC nutrition, 337. https://doi.org/10.1186/s40795-017-0155-1
Hansen, Solvejg L, et al. "Supplementation of docosahexaenoic acid (DHA), vitamin D." BMC nutrition vol. 3 (2017): 37. doi: https://doi.org/10.1186/s40795-017-0155-1
Hansen SL, Ritterband-Rosenbaum A, Voigt CB, Hellgren LI, Sørensen AM, Jacobsen C, Greve LZ, Jørgensen KD, Bilde PE, Kiens B, Nielsen JB. Supplementation of docosahexaenoic acid (DHA), vitamin D. BMC Nutr. 2017 Apr 17;3:37. doi: 10.1186/s40795-017-0155-1. eCollection 2017. PMID: 32153817; PMCID: PMC7050862.
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BMC Nutr. 2017 Apr 17;3:37. doi: 10.1186/s40795-017-0155-1. eCollection 2017.

Supplementation of docosahexaenoic acid (DHA), vitamin D.

BMC nutrition

Solvejg L Hansen, Anina Ritterband-Rosenbaum, Camilla B Voigt, Lars I Hellgren, Ann-Dorit M Sørensen, Charlotte Jacobsen, Line Z Greve, Katrine D Jørgensen, Peder E Bilde, Bente Kiens, Jens B Nielsen

Affiliations

  1. 1Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, August Krogh Building University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark.
  2. 2Center for Neuroscience, Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
  3. The Elsass Institute, Holmegårdsvej 28, 2920 Charlottelund, Denmark.
  4. 3Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark.
  5. 4National Food Institute, Division of Industrial Food Research, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark.

PMID: 32153817 PMCID: PMC7050862 DOI: 10.1186/s40795-017-0155-1

Abstract

BACKGROUND: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect of combining a motor- and cognitive exercise program with dietary supplementation consisting of 500 mg docosahexaenoic acid (DHA), 10 μg vitamin D

METHODS: We designed a randomized, placebo-controlled, double-blinded study lasting 6 weeks in which DDU-supplement or placebo was ingested daily. During the intervention period, all children trained approximately 30 min 3 days/week using an internet-based cognitive and motor training program (Mitii). Prior to and post the intervention period dietary record, blood sampling, physical exercise tests and motor and cognitive tests were performed.

RESULTS: Fourteen of the 16 children completed the intervention and ingested the supplement as required. 6 weeks DDU-supplementation resulted in a significant increase in the blood concentration of vitamin D

CONCLUSION: All children showed improved performance in the trained motor- and cognitive tasks, but it was not possible to demonstrate any significant effects on the cognitive tests from the dietary supplementation. However, DDU-supplementation did result in increased blood concentration of DHA and vitamin D

TRIAL REGISTRATION: Clinical registration ID: NCT02426554 (clinical Trial.gov). January 2015 retrospectively registered.

© The Author(s). 2017.

Keywords: Blood samples; Children; DHA; Nutritional supplement; Pilot study; Training; Uridine; Vitamin D

References

  1. Am J Clin Nutr. 2014 Dec;100(6):1422-36 - PubMed
  2. Brain Res. 2007 Nov 28;1182:50-9 - PubMed
  3. J Nutr. 2010 Apr;140(4):864-8 - PubMed
  4. J Neurotrauma. 2004 Oct;21(10):1457-67 - PubMed
  5. Neuroscience. 2013 Sep 17;248:655-63 - PubMed
  6. Psychiatry Res. 2013 Sep 30;209(2):150-4 - PubMed
  7. PLoS One. 2012;7(8):e42785 - PubMed
  8. Res Dev Disabil. 2014 Apr;35(4):861-70 - PubMed
  9. Ann N Y Acad Sci. 2012 Aug;1264:49-63 - PubMed
  10. Neuropharmacology. 1998 Dec;37(12):1553-61 - PubMed
  11. J Nutr Biochem. 2009 Sep;20(9):735-41 - PubMed
  12. J Nutr. 2005 Nov;135(11):2739S-48S - PubMed
  13. Cold Spring Harb Perspect Biol. 2012 Jun 01;4(6): - PubMed
  14. FASEB J. 2008 Nov;22(11):3938-46 - PubMed
  15. Nat Rev Neurosci. 2008 Jul;9(7):568-78 - PubMed
  16. Res Q Exerc Sport. 2011 Sep;82(3):521-35 - PubMed
  17. Br J Nutr. 2001 Aug;86 Suppl 1:S97-103 - PubMed
  18. Am J Clin Nutr. 2012 Dec;96(6):1327-38 - PubMed
  19. Horm Metab Res. 2013 Jul;45(7):541-4 - PubMed
  20. Am J Clin Nutr. 2007 Oct;86(4):1082-93 - PubMed
  21. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):657-69 - PubMed
  22. J Nutr Health Aging. 2009 Mar;13(3):189-97 - PubMed
  23. Res Dev Disabil. 2010 May-Jun;31(3):718-30 - PubMed
  24. Neuroscience. 2008 Aug 26;155(3):751-9 - PubMed
  25. Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):7-14 - PubMed
  26. BMC Neurol. 2011 Mar 09;11:32 - PubMed
  27. PLoS One. 2012;7(9):e43909 - PubMed
  28. Neuropsychologia. 1971 Mar;9(1):97-113 - PubMed
  29. Nutr Neurosci. 2009 Apr;12(2):48-56 - PubMed
  30. Annu Rev Nutr. 2009;29:59-87 - PubMed
  31. Nutrients. 2014 Jul 22;6(7):2730-58 - PubMed
  32. Ageing Res Rev. 2013 Sep;12(4):1013-23 - PubMed

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