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Boulestreau J, Maumus M, Rozier P, et al. Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging. Front Cell Dev Biol. 2020;8:107doi: 10.3389/fcell.2020.00107.
Boulestreau, J., Maumus, M., Rozier, P., Jorgensen, C., & Noël, D. (2020). Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging. Frontiers in cell and developmental biology, 8107. https://doi.org/10.3389/fcell.2020.00107
Boulestreau, Jérémy, et al. "Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging." Frontiers in cell and developmental biology vol. 8 (2020): 107. doi: https://doi.org/10.3389/fcell.2020.00107
Boulestreau J, Maumus M, Rozier P, Jorgensen C, Noël D. Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging. Front Cell Dev Biol. 2020 Feb 21;8:107. doi: 10.3389/fcell.2020.00107. eCollection 2020. PMID: 32154253; PMCID: PMC7047768.
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Front Cell Dev Biol. 2020 Feb 21;8:107. doi: 10.3389/fcell.2020.00107. eCollection 2020.

Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.

Frontiers in cell and developmental biology

Jérémy Boulestreau, Marie Maumus, Pauline Rozier, Christian Jorgensen, Danièle Noël

Affiliations

  1. Institute of Regenerative Medicine and Biotherapies (IRMB), University of Montpellier, INSERM, Montpellier, France.
  2. Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Department of Rheumatology, CHU, Montpellier, France.

PMID: 32154253 PMCID: PMC7047768 DOI: 10.3389/fcell.2020.00107

Abstract

Aging is associated with high prevalence of chronic degenerative diseases that take a large part of the increasing burden of morbidities in a growing demographic of elderly people. Aging is a complex process that involves cell autonomous and cell non-autonomous mechanisms where senescence plays an important role. Senescence is characterized by the loss of proliferative potential, resistance to cell death by apoptosis and expression of a senescence-associated secretory phenotype (SASP). SASP includes pro-inflammatory cytokines and chemokines, tissue-damaging proteases, growth factors; all contributing to tissue microenvironment alteration and loss of tissue homeostasis. Emerging evidence suggests that the changes in the number and composition of extracellular vesicles (EVs) released by senescent cells contribute to the adverse effects of senescence in aging. In addition, age-related alterations in mesenchymal stem/stromal cells (MSCs) have been associated to dysregulated functions. The loss of functional stem cells necessary to maintain tissue homeostasis likely directly contributes to aging. In this review, we will focus on the characteristics and role of EVs isolated from senescent MSCs, the potential effect of MSC-derived EVs in aging and discuss their therapeutic potential to improve age-related diseases.

Copyright © 2020 Boulestreau, Maumus, Rozier, Jorgensen and Noël.

Keywords: aging; clinical translation; extracellular vesicles; mesenchymal stem cells; regenerative medicine; senescence

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