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Habaybeh D, de Moraes MB, Slee A, et al. Nutritional interventions for heart failure patients who are malnourished or at risk of malnutrition or cachexia: a systematic review and meta-analysis. Heart Fail Rev. 2021;26(5):1103-1118doi: 10.1007/s10741-020-09937-9.
Habaybeh, D., de Moraes, M. B., Slee, A., & Avgerinou, C. (2021). Nutritional interventions for heart failure patients who are malnourished or at risk of malnutrition or cachexia: a systematic review and meta-analysis. Heart failure reviews, 26(5), 1103-1118. https://doi.org/10.1007/s10741-020-09937-9
Habaybeh, Dina, et al. "Nutritional interventions for heart failure patients who are malnourished or at risk of malnutrition or cachexia: a systematic review and meta-analysis." Heart failure reviews vol. 26,5 (2021): 1103-1118. doi: https://doi.org/10.1007/s10741-020-09937-9
Habaybeh D, de Moraes MB, Slee A, Avgerinou C. Nutritional interventions for heart failure patients who are malnourished or at risk of malnutrition or cachexia: a systematic review and meta-analysis. Heart Fail Rev. 2021 Sep;26(5):1103-1118. doi: 10.1007/s10741-020-09937-9. PMID: 32124164; PMCID: PMC8310486.
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Heart Fail Rev. 2021 Sep;26(5):1103-1118. doi: 10.1007/s10741-020-09937-9.

Nutritional interventions for heart failure patients who are malnourished or at risk of malnutrition or cachexia: a systematic review and meta-analysis.

Heart failure reviews

Dina Habaybeh, Mariana Bordinhon de Moraes, Adrian Slee, Christina Avgerinou

Affiliations

  1. Division of Medicine, University College London, London, UK.
  2. Department of Public Health, Botucatu Medical School, São Paulo State University (UNESP), Sao Paulo, Brazil.
  3. Department of Primary Care and Population Health, University College London, Rowland Hill Street, London, NW3 2PF, UK. [email protected].

PMID: 32124164 PMCID: PMC8310486 DOI: 10.1007/s10741-020-09937-9

Abstract

Malnutrition is common in heart failure (HF), and it is associated with higher hospital readmission and mortality rates. This review aims to answer the question whether nutritional interventions aiming to increase protein and energy intake are effective at improving outcomes for patients with HF who are malnourished or at risk of malnutrition or cachexia. Systematic searches of four databases (Medline, Embase, CINAHL and Cochrane Central Register of Controlled Trials (CENTRAL)) were conducted on 21 June 2019. Randomized controlled trials (RCTs) or other interventional studies using protein or energy supplementation for adult HF patients who are malnourished or at risk of malnutrition or cachexia were included. Two independent reviewers assessed study eligibility and risk of bias. Five studies (four RCTs and one pilot RCT) met the inclusion criteria. The majority of studies were small and of limited quality. The pooled weighted mean difference (WMD) for body weight showed a benefit from the nutritional intervention by 3.83 kg (95% confidence interval (CI) 0.17 to 7.50, P = 0.04) from three trials with no significant benefit for triceps skinfold thickness (WMD = - 2.14 mm, 95% CI - 9.07 to 4.79, P = 0.55) from two trials. The combination of personalized nutrition intervention with conventional treatment led to a decrease in all-cause mortality and hospital readmission in one study. Findings of this review suggest that nutritional interventions could potentially improve outcomes in HF patients who are malnourished or at risk of malnutrition. However, the strength of the evidence is poor, and more robust studies with a larger number of participants are needed.

© 2020. The Author(s).

Keywords: Heart failure; Malnutrition; Nutritional interventions; Oral nutritional supplements

References

  1. JACC Heart Fail. 2018 Jun;6(6):476-486 - PubMed
  2. Eur J Cardiovasc Nurs. 2002 Oct;1(3):183-8 - PubMed
  3. Am J Clin Nutr. 2008 Jan;87(1):150-5 - PubMed
  4. J Cachexia Sarcopenia Muscle. 2012 Dec;3(4):213-7 - PubMed
  5. BMC Cardiovasc Disord. 2017 Jul 27;17(1):205 - PubMed
  6. BMJ. 2011 Oct 18;343:d5928 - PubMed
  7. J Cardiovasc Nurs. 2006 Mar-Apr;21(2):123-9 - PubMed
  8. Clin Nutr. 2018 Oct;37(5):1762-1764 - PubMed
  9. Pharmazie. 2006 Mar;61(3):218-22 - PubMed
  10. Am J Cardiol. 2008 Jun 2;101(11A):3E-7E - PubMed
  11. J Physiother Phys Rehabil. 2017;2(2): - PubMed
  12. J Am Coll Cardiol. 2014 Apr 1;63(12):1123-1133 - PubMed
  13. Heart Fail Rev. 2019 Sep;24(5):671-700 - PubMed
  14. PLoS Med. 2009 Jul 21;6(7):e1000097 - PubMed
  15. Clin Med Insights Cardiol. 2014 May 21;8:39-44 - PubMed
  16. Heart Fail Clin. 2017 Jan;13(1):21-28 - PubMed
  17. J Cardiol. 2011 May;57(3):333-7 - PubMed
  18. Clin Nutr. 2016 Feb;35(1):18-26 - PubMed
  19. J Cachexia Sarcopenia Muscle. 2016 Jun;7(3):261-74 - PubMed
  20. J Cachexia Sarcopenia Muscle. 2010 Sep;1(1):35-42 - PubMed
  21. Eur J Heart Fail. 2015 Apr;17(4):424-33 - PubMed
  22. Heart. 2002 Mar;87(3):235-41 - PubMed
  23. Cardiovasc Res. 1995 Sep;30(3):413-8 - PubMed
  24. Int J Cardiol. 2017 Mar 1;230:108-114 - PubMed
  25. Arch Med Res. 2016 Oct;47(7):535-540 - PubMed
  26. Lancet. 1997 Apr 12;349(9058):1050-3 - PubMed
  27. Eur J Heart Fail. 2008 Nov;10(11):1127-35 - PubMed
  28. Arq Bras Cardiol. 2012 Jul;99(1):623-9 - PubMed
  29. Europace. 2011 May;13 Suppl 2:ii13-7 - PubMed
  30. Nutrition. 1999 Feb;15(2):116-22 - PubMed
  31. J Cardiovasc Nurs. 2008 Jul-Aug;23(4):357-63 - PubMed
  32. Heart Fail Clin. 2017 Jul;13(3):417-426 - PubMed
  33. Am J Cardiol. 2008 Jun 2;101(11A):104E-110E - PubMed
  34. Clin Cardiol. 2011 Apr;34(4):211-7 - PubMed
  35. Int J Cardiol. 2015 Jul 15;191:256-64 - PubMed
  36. N Engl J Med. 1964 Aug 20;271:403-9 CONTD - PubMed
  37. Rev Clin Esp (Barc). 2018 Mar;218(2):58-60 - PubMed
  38. Am J Cardiol. 2008 Jun 2;101(11A):89E-103E - PubMed
  39. Int J Cardiol. 2002 Sep;85(1):111-21, discussion 121-4 - PubMed
  40. Eur J Heart Fail. 2002 Jun;4(3):337-43 - PubMed
  41. Curr Opin Clin Nutr Metab Care. 2000 Nov;3(6):417-24 - PubMed
  42. Eur Heart J. 1994 Dec;15(12):1641-50 - PubMed
  43. Clin Nutr. 2016 Feb;35(1):41-47 - PubMed
  44. J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):207-217 - PubMed
  45. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):279-86 - PubMed
  46. Open Heart. 2018 Jan 9;5(1):e000730 - PubMed
  47. J Am Coll Cardiol. 2003 Oct 1;42(7):1218-23 - PubMed
  48. Med Care. 2013 Jan;51(1):52-9 - PubMed

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