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Ang R, Marina N. Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity. Front Physiol. 2020;11:236doi: 10.3389/fphys.2020.00236.
Ang, R., & Marina, N. (2020). Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity. Frontiers in physiology, 11236. https://doi.org/10.3389/fphys.2020.00236
Ang, Richard, and Marina, Nephtali. "Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity." Frontiers in physiology vol. 11 (2020): 236. doi: https://doi.org/10.3389/fphys.2020.00236
Ang R, Marina N. Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity. Front Physiol. 2020 Mar 18;11:236. doi: 10.3389/fphys.2020.00236. eCollection 2020. PMID: 32256390; PMCID: PMC7093552.
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Front Physiol. 2020 Mar 18;11:236. doi: 10.3389/fphys.2020.00236. eCollection 2020.

Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity.

Frontiers in physiology

Richard Ang, Nephtali Marina

Affiliations

  1. Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
  2. Division of Medicine, University College London, London, United Kingdom.

PMID: 32256390 PMCID: PMC7093552 DOI: 10.3389/fphys.2020.00236

Abstract

Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patients post-myocardial infarction that is believed to occur in association with low-frequency oscillations in sympathetic nerve activity. However, this hypothesis is based on associations of PRD with indices of sympathetic activity that are not directly linked to cardiac function, such as muscle vasoconstrictor activity and the variability of cardiovascular autospectra. In this review article, we critically evaluate existing scientific evidence obtained primarily in experimental animal models, with the aim of identifying the neuronal networks responsible for the generation of low-frequency sympathetic rhythms along the neurocardiac axis. We discuss the functional significance of rhythmic sympathetic activity on neurotransmission efficacy and explore its role in the pathogenesis of ventricular repolarization instability. Most importantly, we discuss important gaps in our knowledge that require further investigation in order to confirm the hypothesis that low frequency cardiac sympathetic oscillations play a causative role in the generation of PRD.

Copyright © 2020 Ang and Marina.

Keywords: arrhythmia; cardiac innervation; cardiac repolarization; oscillations; sympathetic

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