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J Clin Transl Sci. 2019 Dec 26;4(1):43-52. doi: 10.1017/cts.2019.424. eCollection 2020 Feb.

KL2 mentored career development programs at clinical and translational science award hubs: Practices and outcomes.

Journal of clinical and translational science

Christine A Sorkness, Linda Scholl, Alecia M Fair, Jason G Umans

Affiliations

  1. Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI, USA.
  2. Meharry-Vanderbilt Alliance, Nashville, TN, USA.
  3. Georgetown-Howard Universities Center for Clinical Translational Science, Washington, DC, USA.

PMID: 32257410 PMCID: PMC7103475 DOI: 10.1017/cts.2019.424

Abstract

INTRODUCTION: NIH Clinical and Translational Science Awards (CTSAs) include KL2 mentored career development awards for faculty commencing clinical and translational research. A survey of KL2 leaders revealed program practices, curricular elements and compelling data about scholar characteristics and outcomes.

METHODS: We conducted a literature review, framed the survey construct, and obtained input from across the CTSA consortium. A REDCap survey was emailed in fall 2016 to 61 active programs.

RESULTS: Fifty-five programs (90.2%) responded. Respondents had been funded from 3 to 11 years, including 22 "mature" hubs funded for ≥8 years. Program cohort sizes were 56% "small", 22% "medium", and 22% "large." Hubs offer extensive competency-aligned training opportunities relevant to clinical and translational research, including graduate degrees, mentorship, and grant-writing. Seventy-two percent of hubs report parallel "KL2-equivalent" career development programs. All hubs share their training and facilitate intermingling with other early stage investigators. A total of 1,517 KL2 scholars were funded. KL2 awardees are diverse in their disciplines, research projects, and representation; 54% are female and 12% self-identified as underrepresented in biomedical research. Eighty-seven percent of scholars have 2-3 mentors and are currently supported for 2-3 years. Seventy-eight percent of alumni remain at CTSA institutions in translational science. The most common form of NIH support following scholars' KL2 award is an individual career development award.

CONCLUSIONS: The KL2 is a unique career development award, shaped by competency-aligned training opportunities and interdisciplinary mentorship that inform translational research pathways. Tracking both traditional and novel outcomes of KL2 scholars is essential to capture their career trajectories and impact on health.

© The Association for Clinical and Translational Science 2019.

Keywords: Mentored career development; clinical and translational research workforce; clinical and translational science awards; survey outcomes; training curriculum

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