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Amadi-Kamalu C, Clarke H, McRobie M, et al. Investigation of Parameters that Affect Resin Swelling in Green Solvents. ChemistryOpen. 2020;9(4):431-441doi: 10.1002/open.202000030.
Amadi-Kamalu, C., Clarke, H., McRobie, M., Mortimer, J., North, M., Ran, Y., Routledge, A., Sibbald, D., Tickias, M., Tse, K., & Willway, H. (2020). Investigation of Parameters that Affect Resin Swelling in Green Solvents. ChemistryOpen, 9(4), 431-441. https://doi.org/10.1002/open.202000030
Amadi-Kamalu, Chidi, et al. "Investigation of Parameters that Affect Resin Swelling in Green Solvents." ChemistryOpen vol. 9,4 (2020): 431-441. doi: https://doi.org/10.1002/open.202000030
Amadi-Kamalu C, Clarke H, McRobie M, Mortimer J, North M, Ran Y, Routledge A, Sibbald D, Tickias M, Tse K, Willway H. Investigation of Parameters that Affect Resin Swelling in Green Solvents. ChemistryOpen. 2020 Apr 03;9(4):431-441. doi: 10.1002/open.202000030. eCollection 2020 Apr. PMID: 32257751; PMCID: PMC7121665.
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ChemistryOpen. 2020 Apr 03;9(4):431-441. doi: 10.1002/open.202000030. eCollection 2020 Apr.

Investigation of Parameters that Affect Resin Swelling in Green Solvents.

ChemistryOpen

Chidi Amadi-Kamalu, Holly Clarke, Matthew McRobie, James Mortimer, Michael North, Yanrui Ran, Anne Routledge, Dani Sibbald, Matthew Tickias, Kai Tse, Helen Willway

Affiliations

  1. Department of Chemistry University of York York UK YO10 5DD.

PMID: 32257751 PMCID: PMC7121665 DOI: 10.1002/open.202000030

Abstract

The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.

© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Keywords: ChemMatrix; peptide; polystyrene; solvent; swelling

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