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Zachari M, Ktistakis NT. Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps. Front Cell Dev Biol. 2020;8:171doi: 10.3389/fcell.2020.00171.
Zachari, M., & Ktistakis, N. T. (2020). Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps. Frontiers in cell and developmental biology, 8171. https://doi.org/10.3389/fcell.2020.00171
Zachari, Maria, and Ktistakis, Nicholas T. "Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps." Frontiers in cell and developmental biology vol. 8 (2020): 171. doi: https://doi.org/10.3389/fcell.2020.00171
Zachari M, Ktistakis NT. Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps. Front Cell Dev Biol. 2020 Mar 18;8:171. doi: 10.3389/fcell.2020.00171. eCollection 2020. PMID: 32258042; PMCID: PMC7093328.
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Front Cell Dev Biol. 2020 Mar 18;8:171. doi: 10.3389/fcell.2020.00171. eCollection 2020.

Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps.

Frontiers in cell and developmental biology

Maria Zachari, Nicholas T Ktistakis

Affiliations

  1. MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, United Kingdom.
  2. Signalling Programme, Babraham Institute, Cambridge, United Kingdom.

PMID: 32258042 PMCID: PMC7093328 DOI: 10.3389/fcell.2020.00171

Abstract

Mitophagy, a conserved intracellular process by which mitochondria are eliminated via the autophagic machinery, is a quality control mechanism which facilitates maintenance of a functional mitochondrial network and cell homeostasis, making it a key process in development and longevity. Mitophagy has been linked to multiple human disorders, especially neurodegenerative diseases where the long-lived neurons are relying on clearance of old/damaged mitochondria to survive. During the past decade, the availability of novel tools to study mitophagy both

Copyright © 2020 Zachari and Ktistakis.

Keywords: autophagy; endoplasmic reticulum; mTOR; membrane potential; mitophagy

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