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Kanchanasurakit S, Arsu A, Siriplabpla W, et al. Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis. Kidney Res Clin Pract. 2020;39(1):81-92doi: 10.23876/j.krcp.19.106.
Kanchanasurakit, S., Arsu, A., Siriplabpla, W., Duangjai, A., & Saokaew, S. (2020). Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis. Kidney research and clinical practice, 39(1), 81-92. https://doi.org/10.23876/j.krcp.19.106
Kanchanasurakit, Sukrit, et al. "Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis." Kidney research and clinical practice vol. 39,1 (2020): 81-92. doi: https://doi.org/10.23876/j.krcp.19.106
Kanchanasurakit S, Arsu A, Siriplabpla W, Duangjai A, Saokaew S. Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis. Kidney Res Clin Pract. 2020 Mar 31;39(1):81-92. doi: 10.23876/j.krcp.19.106. PMID: 32172553; PMCID: PMC7105620.
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Kidney Res Clin Pract. 2020 Mar 31;39(1):81-92. doi: 10.23876/j.krcp.19.106.

Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis.

Kidney research and clinical practice

Sukrit Kanchanasurakit, Aimusa Arsu, Wuttikorn Siriplabpla, Acharaporn Duangjai, Surasak Saokaew

Affiliations

  1. Division of Pharmacy Practice, Department of Pharmaceutical Care, School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand.
  2. Department of Pharmacy, Phrae Hospital, Phrae, Thailand.
  3. Department of Medicine, Phrae Hospital, Phrae, Thailand.
  4. School of Medical Sciences, University of Phayao, Phayao, Thailand.
  5. Unit of Excellence on Clinical Outcomes Research and IntegratioN (UNICORN), School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand.
  6. Unit of Excellence on Herbal Medicine, School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand.
  7. Center of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand.
  8. Biofunctional Molecule Exploratory Research Group, Biomedicine Research Advancement Centre, School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia.
  9. Novel Bacteria and Drug Discovery Research Group, Microbiome and Bioresource Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.

PMID: 32172553 PMCID: PMC7105620 DOI: 10.23876/j.krcp.19.106

Abstract

BACKGROUND: Acetaminophen is commonly used for the relief of pain and fever. Advocacy organizations recommend acetaminophen as the drug of choice in patients with kidney disease. Although some studies have suggested a risk of renal impairment after the use of acetaminophen, the effect of acetaminophen on the risk of renal impairment is unclear. The purpose of this research was to demonstrate any correlation linking acetaminophen treatment and renal impairment.

METHODS: We performed a systematic review and meta-analysis of the association between acetaminophen and renal impairment in adults by searching Cochrane Library, PubMed, and Embase databases from initiation to June 16, 2019.

RESULTS: Of 13,097 articles identified, 5 studies (2 cohort studies and 3 case-control studies) with a total of 13,114 participants were included. In the random-effects meta-analysis of the cohort study, acetaminophen use was shown to have statistically significant effects on the increased risk of renal impairment (adjusted odds ratio 1.23; 95% confidence interval, 1.07-1.40). The results of sensitivity and subgroup analyses also suggested that acetaminophen use increases the risk of renal impairment. The Egger's test (

CONCLUSION: Acetaminophen is associated with a significantly increased risk of newly developing renal impairment in adults. Physicians who prescribe acetaminophen should be aware of potential adverse renal effects. A longitudinal study that further explores this association is warranted.

Keywords: Acetaminophen; Acute kidney injury; Kidney disease; Renal insufficiency

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