Display options
Cite
Andrès E, Lorenzo Villalba N, Mourot-Cottet R, et al. Severe Neutropenia and Agranulocytosis Related to Antithyroid Drugs: A Study of 30 Cases Managed in A Single Reference Center. Medicines (Basel). 2020;7(3)doi: 10.3390/medicines7030015.
Andrès, E., Lorenzo Villalba, N., Mourot-Cottet, R., Maloisel, F., Tebacher, M., Gottenberg, J. E., Goichot, B., Herbrecht, R., & Zulfiqar, A. A. (2020). Severe Neutropenia and Agranulocytosis Related to Antithyroid Drugs: A Study of 30 Cases Managed in A Single Reference Center. Medicines (Basel, Switzerland), 7(3), . https://doi.org/10.3390/medicines7030015
Andrès, Emmanuel, et al. "Severe Neutropenia and Agranulocytosis Related to Antithyroid Drugs: A Study of 30 Cases Managed in A Single Reference Center." Medicines (Basel, Switzerland) vol. 7,3 (2020). doi: https://doi.org/10.3390/medicines7030015
Andrès E, Lorenzo Villalba N, Mourot-Cottet R, Maloisel F, Tebacher M, Gottenberg JE, Goichot B, Herbrecht R, Zulfiqar AA. Severe Neutropenia and Agranulocytosis Related to Antithyroid Drugs: A Study of 30 Cases Managed in A Single Reference Center. Medicines (Basel). 2020 Mar 19;7(3). doi: 10.3390/medicines7030015. PMID: 32204561; PMCID: PMC7151575.
Copy Download .nbib Format: NLM
Share it on

Medicines (Basel). 2020 Mar 19;7(3). doi: 10.3390/medicines7030015.

Severe Neutropenia and Agranulocytosis Related to Antithyroid Drugs: A Study of 30 Cases Managed in A Single Reference Center.

Medicines (Basel, Switzerland)

Emmanuel Andrès, Noel Lorenzo Villalba, Rachel Mourot-Cottet, Frédéric Maloisel, Martine Tebacher, Jacques-Eric Gottenberg, Bernard Goichot, Raoul Herbrecht, Abrar-Ahmad Zulfiqar

Affiliations

  1. Departments of Internal Medicine, Strasbourg University Hospitals, 67000 Strasbourg, France.
  2. Onco-Hematology, Strasbourg University Hospitals, 67000 Strasbourg, France.
  3. Regional Pharmacovigilance Centre of Alsace, 67000 Strasbourg, France.
  4. Rheumatology, Strasbourg University Hospitals, 67000 Strasbourg, France.

PMID: 32204561 PMCID: PMC7151575 DOI: 10.3390/medicines7030015

Abstract

BACKGROUND: The most important series devoted to antithyroid drug-induced severe neutropenia and agranulocytosis are Japanese studies, almost specifically in relation to the intake of methimazole. The clinical data of 30 Caucasian patients followed up for antithyroid drug-induced neutropenia at a third-level hospital are reported.

Keywords: agranulocytosis; antithyroid drug; carbimazole; diagnosis; fever; granulocyte colony-stimulating factor; hematopoietic growth factor; infection; neutropenia; propylthiouracil

Conflict of interest statement

E.A. is the recipient of several grants from different laboratories: Novartis, BMS, Pfizer, Léo Pharma, Boehringer, Servier, Aspen, Ferring, and Air Liquide but these sponsors have no part in the rese

References

  1. Drugs R D. 2017 Mar;17(1):91-96 - PubMed
  2. Expert Rev Hematol. 2011 Apr;4(2):143-51 - PubMed
  3. Nouv Rev Fr Hematol. 1991;33(3):257-62 - PubMed
  4. J Clin Endocrinol Metab. 2012 Jan;97(1):E49-53 - PubMed
  5. Thyroid. 1999 Jan;9(1):29-31 - PubMed
  6. Endocr Connect. 2017 May;6(4):200-205 - PubMed
  7. Haematologica. 2003 Apr;88(4):470-1 - PubMed
  8. Ann Intern Med. 2007 May 1;146(9):657-65 - PubMed
  9. QJM. 2001 Aug;94(8):423-8 - PubMed
  10. Arch Intern Med. 1990 Mar;150(3):621-4 - PubMed
  11. J Endocrinol Invest. 1994 Jan;17(1):29-36 - PubMed
  12. Thyroid. 2005 Mar;15(3):292-7 - PubMed
  13. QJM. 2017 Jan 9;110(5):299-305 - PubMed
  14. Eur J Intern Med. 2002 Aug;13(5):324-328 - PubMed
  15. Ann Intern Med. 1983 Jan;98(1):26-9 - PubMed
  16. Clin Endocrinol (Oxf). 1989 May;30(5):525-30 - PubMed
  17. Eur J Haematol Suppl. 1996;60:6-8 - PubMed
  18. Br J Clin Pract. 1988 Nov;42(11):474-5 - PubMed
  19. BMJ. 1988 Jul 23;297(6643):262-5 - PubMed
  20. Rev Med Interne. 2016 Aug;37(8):544-50 - PubMed
  21. Clin Endocrinol (Oxf). 2004 Nov;61(5):589-94 - PubMed
  22. Br J Haematol. 1991 Nov;79(3):366-71 - PubMed
  23. Eur Thyroid J. 2016 Dec;5(4):253-260 - PubMed
  24. N Engl J Med. 2005 Mar 3;352(9):905-17 - PubMed

Publication Types