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Liu TY, Ho JY, Wei JC, et al. Label-free and culture-free microbe detection by three dimensional hot-junctions of flexible Raman-enhancing nanohybrid platelets. J Mater Chem B. 2014;2(9):1136-1143doi: 10.1039/c3tb21469a.
Liu, T. Y., Ho, J. Y., Wei, J. C., Cheng, W. C., Chen, I. H., Shiue, J., Wang, H. H., Wang, J. K., Wang, Y. L., & Lin, J. J. (2014). Label-free and culture-free microbe detection by three dimensional hot-junctions of flexible Raman-enhancing nanohybrid platelets. Journal of materials chemistry. B, 2(9), 1136-1143. https://doi.org/10.1039/c3tb21469a
Liu, Ting-Yu, et al. "Label-free and culture-free microbe detection by three dimensional hot-junctions of flexible Raman-enhancing nanohybrid platelets." Journal of materials chemistry. B vol. 2,9 (2014): 1136-1143. doi: https://doi.org/10.1039/c3tb21469a
Liu TY, Ho JY, Wei JC, Cheng WC, Chen IH, Shiue J, Wang HH, Wang JK, Wang YL, Lin JJ. Label-free and culture-free microbe detection by three dimensional hot-junctions of flexible Raman-enhancing nanohybrid platelets. J Mater Chem B. 2014 Mar 07;2(9):1136-1143. doi: 10.1039/c3tb21469a. Epub 2014 Jan 23. PMID: 32261349.
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J Mater Chem B. 2014 Mar 07;2(9):1136-1143. doi: 10.1039/c3tb21469a. Epub 2014 Jan 23.

Label-free and culture-free microbe detection by three dimensional hot-junctions of flexible Raman-enhancing nanohybrid platelets.

Journal of materials chemistry. B

Ting-Yu Liu, Jun-Ying Ho, Jiun-Chiou Wei, Wei-Chih Cheng, I-Hui Chen, Jessie Shiue, Huai-Hsien Wang, Juen-Kai Wang, Yuh-Lin Wang, Jiang-Jen Lin

Affiliations

  1. Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan. [email protected] [email protected].

PMID: 32261349 DOI: 10.1039/c3tb21469a

Abstract

Novel nanohybrid arrays of silver (Ag)-on-silicate platelets with flexibility and three-dimensional (3D) hot-junctions (particularly in z-direction) were discovered for improving the stability of free nanoparticles and the mobility of rigid (glass or silicon-based) substrates in surface-enhanced Raman scattering (SERS) detection technology. Since the Ag nanoparticles are adsorbed on both sides of few nanometer-thick silicate platelets (single-layer exfoliated clay), the geometric arrangement of Ag on both sides of the nanoplatelets (Ag/NSP) may induce strong hot-junctions (z-direction) in reference to the pristine montmorillonite clay (multi-layers) at the thickness of ∼20 nm, measured by small molecules (adenine of DNA) and bacteria (S. aureus). Enormous red-shifts (16 nm wavelength difference) were observed between single layer and multi-layer silicate platelets, showing that huge surface plasmon enhancement comes from hot junctions in the z-direction (∼7 times higher than 2D hot-junctions of traditional SERS biochips). Further, the Ag/NSP SERS substrate displays a free floating mobility and optical transparency (less background interference), which inherently increase the contacted surface-area between the substrate and microorganisms, to enhance the SERS sensitivity. The surface modulation with a surfactant could be complimentary towards a variety of microorganisms including hydrophobic microbes, irregular-shaped microorganisms and larger biological cells due to their mutual specific surface interactions. It was anticipated to apply in the rapid detection for varied microbes with label-free and culture-free characterizations.

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