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Mauchauffé R, Moreno-Couranjou M, Boscher ND, et al. Robust bio-inspired antibacterial surfaces based on the covalent binding of peptides on functional atmospheric plasma thin films. J Mater Chem B. 2014;2(32):5168-5177doi: 10.1039/c4tb00503a.
Mauchauffé, R., Moreno-Couranjou, M., Boscher, N. D., Van De Weerdt, C., Duwez, A. S., & Choquet, P. (2014). Robust bio-inspired antibacterial surfaces based on the covalent binding of peptides on functional atmospheric plasma thin films. Journal of materials chemistry. B, 2(32), 5168-5177. https://doi.org/10.1039/c4tb00503a
Mauchauffé, Rodolphe, et al. "Robust bio-inspired antibacterial surfaces based on the covalent binding of peptides on functional atmospheric plasma thin films." Journal of materials chemistry. B vol. 2,32 (2014): 5168-5177. doi: https://doi.org/10.1039/c4tb00503a
Mauchauffé R, Moreno-Couranjou M, Boscher ND, Van De Weerdt C, Duwez AS, Choquet P. Robust bio-inspired antibacterial surfaces based on the covalent binding of peptides on functional atmospheric plasma thin films. J Mater Chem B. 2014 Aug 28;2(32):5168-5177. doi: 10.1039/c4tb00503a. Epub 2014 Jul 07. PMID: 32261658.
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J Mater Chem B. 2014 Aug 28;2(32):5168-5177. doi: 10.1039/c4tb00503a. Epub 2014 Jul 07.

Robust bio-inspired antibacterial surfaces based on the covalent binding of peptides on functional atmospheric plasma thin films.

Journal of materials chemistry. B

Rodolphe Mauchauffé, Maryline Moreno-Couranjou, Nicolas D Boscher, Cécile Van De Weerdt, Anne-Sophie Duwez, Patrick Choquet

Affiliations

  1. Science and Analysis of Materials Department, Centre de Recherche Public - Gabriel Lippmann, Belvaux, L-4422, Luxembourg. [email protected].

PMID: 32261658 DOI: 10.1039/c4tb00503a

Abstract

Here, we describe a robust process aiming at conferring antibacterial properties on stainless steel through the covalent grafting of nisin, a natural antimicrobial peptide, onto a functional plasma thin film deposited by an atmospheric pressure dielectric barrier discharge process. The three different steps of the procedure, namely the deposition of a carboxyl rich thin layer, the surface activation by using a zero-length crosslinking agent and the nisin immobilisation, are reported and thoroughly characterised. A correlation between the carboxylic group surface concentration and the surface roughness onto the antibacterial properties of the layers is evidenced. Finally, IR analyses appear as a powerful analytical tool allowing us to validate the different chemical surface modifications, to confirm the relevance of the activation step to achieve a stable and homogenous peptide grafting over all the surfaces, as well as to investigate the secondary structure of immobilized peptides.

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