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Susarrey-Arce A, Sorzabal-Bellido I, Oknianska A, et al. Bacterial viability on chemically modified silicon nanowire arrays. J Mater Chem B. 2016;4(18):3104-3112doi: 10.1039/c6tb00460a.
Susarrey-Arce, A., Sorzabal-Bellido, I., Oknianska, A., McBride, F., Beckett, A. J., Gardeniers, J. G. E., Raval, R., Tiggelaar, R. M., & Diaz Fernandez, Y. A. (2016). Bacterial viability on chemically modified silicon nanowire arrays. Journal of materials chemistry. B, 4(18), 3104-3112. https://doi.org/10.1039/c6tb00460a
Susarrey-Arce, A, et al. "Bacterial viability on chemically modified silicon nanowire arrays." Journal of materials chemistry. B vol. 4,18 (2016): 3104-3112. doi: https://doi.org/10.1039/c6tb00460a
Susarrey-Arce A, Sorzabal-Bellido I, Oknianska A, McBride F, Beckett AJ, Gardeniers JGE, Raval R, Tiggelaar RM, Diaz Fernandez YA. Bacterial viability on chemically modified silicon nanowire arrays. J Mater Chem B. 2016 May 14;4(18):3104-3112. doi: 10.1039/c6tb00460a. Epub 2016 Mar 15. PMID: 32263048.
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J Mater Chem B. 2016 May 14;4(18):3104-3112. doi: 10.1039/c6tb00460a. Epub 2016 Mar 15.

Bacterial viability on chemically modified silicon nanowire arrays.

Journal of materials chemistry. B

A Susarrey-Arce, I Sorzabal-Bellido, A Oknianska, F McBride, A J Beckett, J G E Gardeniers, R Raval, R M Tiggelaar, Y A Diaz Fernandez

Affiliations

  1. Open Innovation Hub for Antimicrobial Surfaces at the Surface Science Research Centre, University of Liverpool, Oxford Street, L69 3BX, Liverpool, UK. [email protected] [email protected] [email protected].

PMID: 32263048 DOI: 10.1039/c6tb00460a

Abstract

The global threat of antimicrobial resistance is driving an urgent need for novel antimicrobial strategies. Functional surfaces are essential to prevent spreading of infection and reduce surface contamination. In this study we have fabricated and characterized multiscale-functional nanotopographies with three levels of functionalization: (1) nanostructure topography in the form of silicon nanowires, (2) covalent chemical modification with (3-aminopropyl)triethoxysilane, and (3) incorporation of chlorhexidine digluconate. Cell viability assays were carried out on two model microorganisms E. coli and S. aureus over these nanotopographic surfaces. Using SEM we have identified two growth modes producing distinctive multicellular structures, i.e. in plane growth for E. coli and out of plane growth for S. aureus. We have also shown that these chemically modified SiNWs arrays are effective in reducing the number of planktonic and surface-attached microorganisms.

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