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Kakde D, Taresco V, Bansal KK, et al. Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release. J Mater Chem B. 2016;4(44):7119-7129doi: 10.1039/c6tb01839d.
Kakde, D., Taresco, V., Bansal, K. K., Magennis, E. P., Howdle, S. M., Mantovani, G., Irvine, D. J., & Alexander, C. (2016). Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release. Journal of materials chemistry. B, 4(44), 7119-7129. https://doi.org/10.1039/c6tb01839d
Kakde, Deepak, et al. "Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release." Journal of materials chemistry. B vol. 4,44 (2016): 7119-7129. doi: https://doi.org/10.1039/c6tb01839d
Kakde D, Taresco V, Bansal KK, Magennis EP, Howdle SM, Mantovani G, Irvine DJ, Alexander C. Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release. J Mater Chem B. 2016 Nov 28;4(44):7119-7129. doi: 10.1039/c6tb01839d. Epub 2016 Oct 20. PMID: 32263649.
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J Mater Chem B. 2016 Nov 28;4(44):7119-7129. doi: 10.1039/c6tb01839d. Epub 2016 Oct 20.

Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release.

Journal of materials chemistry. B

Deepak Kakde, Vincenzo Taresco, Kuldeep K Bansal, E Peter Magennis, Steven M Howdle, Giuseppe Mantovani, Derek J Irvine, Cameron Alexander

Affiliations

  1. School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. [email protected].

PMID: 32263649 DOI: 10.1039/c6tb01839d

Abstract

Here we describe a methoxy poly(ethyleneglycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer and investigate the potential of the copolymer as a vehicle for solubilisation and sustained release of indomethacin (IND). The indomethacin loading and release from mPEG-b-PεDL micelles (amorphous cores) was compared against methoxy poly(ethyleneglycol)-b-poly(ε-caprolactone)(mPEG-b-PCL) micelles (semicrystalline cores). The drug-polymer compatibility was determined through a theoretical approach to predict drug incorporation into hydrated micelles. Polymer micelles were prepared by solvent evaporation and characterised for size, morphology, indomethacin loading and release. All the formulations generated spherical micelles but significantly larger mPEG-b-PεDL micelles were observed compared to mPEG-b-PCL micelles. A higher compatibility of the drug was predicted for PCL cores based on Flory-Huggins interaction parameters (χ

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