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Deschenes PC, Autmizguine J, Major P, et al. Valproic Acid Induced Pancreatitis Presenting With Decreased Level of Consciousness in a Child With Tuberous Sclerosis Complex. J Pediatr Pharmacol Ther. 2020;25(3):256-260doi: 10.5863/1551-6776-25.3.256.
Deschenes, P. C., Autmizguine, J., Major, P., & Kleiber, N. (2020). Valproic Acid Induced Pancreatitis Presenting With Decreased Level of Consciousness in a Child With Tuberous Sclerosis Complex. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 25(3), 256-260. https://doi.org/10.5863/1551-6776-25.3.256
Deschenes, Pierre-Charles, et al. "Valproic Acid Induced Pancreatitis Presenting With Decreased Level of Consciousness in a Child With Tuberous Sclerosis Complex." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 25,3 (2020): 256-260. doi: https://doi.org/10.5863/1551-6776-25.3.256
Deschenes PC, Autmizguine J, Major P, Kleiber N. Valproic Acid Induced Pancreatitis Presenting With Decreased Level of Consciousness in a Child With Tuberous Sclerosis Complex. J Pediatr Pharmacol Ther. 2020;25(3):256-260. doi: 10.5863/1551-6776-25.3.256. PMID: 32265611; PMCID: PMC7134590.
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J Pediatr Pharmacol Ther. 2020;25(3):256-260. doi: 10.5863/1551-6776-25.3.256.

Valproic Acid Induced Pancreatitis Presenting With Decreased Level of Consciousness in a Child With Tuberous Sclerosis Complex.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Pierre-Charles Deschenes, Julie Autmizguine, Philippe Major, Niina Kleiber

PMID: 32265611 PMCID: PMC7134590 DOI: 10.5863/1551-6776-25.3.256

Abstract

A 2-year-old Caucasian boy with tuberous sclerosis complex presented to the emergency department with lethargy and new onset myoclonias. Pancreatitis, thrombocytopenia, and coagulopathy associated to a decreased level of consciousness were diagnosed. Valproic acid had been initiated 13 months before and had been slowly increased to a dose of approximately 38 mg/kg/day. All the symptoms resolved after discontinuation of the medication. The clinical presentation of this child highlights that valproic acid-related pancreatitis can present with decreased level of consciousness without associated gastrointestinal symptoms. Adverse drug reactions associated with valproic acid can lead to damage of multiple organs and may prove fatal if not promptly recognized and managed.

Copyright Pediatric Pharmacy Association. All rights reserved. For permissions, email: [email protected] 2020.

Keywords: adverse drug effect; adverse drug reaction; pancreatitis; seizures; side effect; tuberous sclerosis complex; valproic acid

Conflict of interest statement

Disclosure The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria. The

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