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Fernández-Nogueira P, Mancino M, Fuster G, et al. Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy. J Clin Med. 2020;9(3)doi: 10.3390/jcm9030776.
Fernández-Nogueira, P., Mancino, M., Fuster, G., Bragado, P., Puig, M. P., Gascón, P., Casado, F. J., & Carbó, N. (2020). Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy. Journal of clinical medicine, 9(3), . https://doi.org/10.3390/jcm9030776
Fernández-Nogueira, Patricia, et al. "Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy." Journal of clinical medicine vol. 9,3 (2020). doi: https://doi.org/10.3390/jcm9030776
Fernández-Nogueira P, Mancino M, Fuster G, Bragado P, Puig MP, Gascón P, Casado FJ, Carbó N. Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy. J Clin Med. 2020 Mar 12;9(3). doi: 10.3390/jcm9030776. PMID: 32178425; PMCID: PMC7141321.
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J Clin Med. 2020 Mar 12;9(3). doi: 10.3390/jcm9030776.

Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy.

Journal of clinical medicine

Patricia Fernández-Nogueira, Mario Mancino, Gemma Fuster, Paloma Bragado, Miquel Prats de Puig, Pere Gascón, Francisco Javier Casado, Neus Carbó

Affiliations

  1. Institut d'Investigacions Biomèdiques Augustí Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
  2. Department of Biochemistry and Molecular Biomedicine, University of Barcelona; Institute of Biomedicine, University of Barcelona (IBUB), 08028 Barcelona, Spain.
  3. Department of Medicine, University of Barcelona, 08036 Barcelona, Spain.
  4. Department of Biochemistry & Physiology, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
  5. Department of Biosciences, Faculty of Sciences and Technology, University of Vic, 08500 Vic, Spain.
  6. Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid; Health Research Institute of the Hospital Clínico San Carlos, 28040 Madrid, Spain.
  7. Head of the Breast Committee, Hospital El Pilar, Quirón salud Group, 08006 Barcelona, Spain.
  8. Director, Chair of Oncology and Multidisciplinary Knowledge, 08036 Barcelona, Spain.

PMID: 32178425 PMCID: PMC7141321 DOI: 10.3390/jcm9030776

Abstract

Current evidences state clear that both normal development of breast tissue as well as its malignant progression need many-sided local and systemic communications between epithelial cells and stromal components. During development, the stroma, through remarkably regulated contextual signals, affects the fate of the different mammary cells regarding their specification and differentiation. Likewise, the stroma can generate tumour environments that facilitate the neoplastic growth of the breast carcinoma. Mammographic density has been described as a risk factor in the development of breast cancer and is ascribed to modifications in the composition of breast tissue, including both stromal and glandular compartments. Thus, stroma composition can dramatically affect the progression of breast cancer but also its early detection since it is mainly responsible for the differences in mammographic density among individuals. This review highlights both the pathological and biological evidences for a pivotal role of the breast stroma in mammographic density, with particular emphasis on dense and malignant stromas, their clinical meaning and potential therapeutic implications for breast cancer patients.

Keywords: ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC), breast cancer detection; mammographic density; therapy resistance; tumour stroma

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