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Reinehr T, Carlsson M, Chrysis D, et al. Adult height prediction by bone age determination in children with isolated growth hormone deficiency. Endocr Connect. 2020;9(5):370-378doi: 10.1530/EC-20-0090.
Reinehr, T., Carlsson, M., Chrysis, D., & Camacho-Hübner, C. (2020). Adult height prediction by bone age determination in children with isolated growth hormone deficiency. Endocrine connections, 9(5), 370-378. https://doi.org/10.1530/EC-20-0090
Reinehr, Thomas, et al. "Adult height prediction by bone age determination in children with isolated growth hormone deficiency." Endocrine connections vol. 9,5 (2020): 370-378. doi: https://doi.org/10.1530/EC-20-0090
Reinehr T, Carlsson M, Chrysis D, Camacho-Hübner C. Adult height prediction by bone age determination in children with isolated growth hormone deficiency. Endocr Connect. 2020 May;9(5):370-378. doi: 10.1530/EC-20-0090. PMID: 32268296; PMCID: PMC7219136.
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Endocr Connect. 2020 May;9(5):370-378. doi: 10.1530/EC-20-0090.

Adult height prediction by bone age determination in children with isolated growth hormone deficiency.

Endocrine connections

Thomas Reinehr, Martin Carlsson, Dionisios Chrysis, Cecilia Camacho-Hübner

Affiliations

  1. Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Children's Hospital, University of Witten/Herdecke, Datteln, Germany.
  2. Endocrine Care, Pfizer Inc, New York, New York, USA.
  3. Division of Pediatric Endocrinology, University of Patras, Patras, Greece.

PMID: 32268296 PMCID: PMC7219136 DOI: 10.1530/EC-20-0090

Abstract

BACKGROUND: The precision of adult height prediction by bone age determination in children with idiopathic growth hormone deficiency (IGHD) is unknown.

METHODS: The near adult height (NAH) of patients with IGHD in the KIGS database was compared retrospectively to adult height prediction calculated by the Bayley-Pinneau (BP) prediction based on bone age by Greulich-Pyle (GP) in 315 children and based on the Tanner-Whitehouse 2 (TW2) method in 121 children. Multiple linear regression analyses adjusted for age at GH start, age at puberty, mean dose and years of of GH treatment, and maximum GH peak in stimulation test were calculated.

RESULTS: The mean underestimation of adult height based on the BP method was at baseline 4.1 ± 0.7 cm in girls and 6.1 ± 0.6 cm in boys, at 1 year of GH treatment 2.5 ± 0.5 cm in girls and 0.9 ± 0.4 cm in boys, while at last bone age determination adult height was overestimated in mean by 0.4 ± 0.6 cm in girls and 3.8 ± 0.5 cm in boys. The mean underestimation of adult height based on the TW2 method was at baseline 5.3 ± 2.0 cm in girls and 7.9 ± 0.8 cm in boys, at 1 year of GH treatment adult height was overestimated in girls 0.1 ± 0.6 cm in girls and underestimated 4.1 ± 0.4 cm in boys, while at last bone age determination adult height was overestimated in mean by 3.1 ± 1.5 cm in girls and 3.6 ± 0.8 cm in boys.

CONCLUSIONS: Height prediction by BP and TW2 at onset of GH treatment underestimates adult height in prepubertal IGHD children, while in mean 6 years after onset of GH treatment these prediction methods overestimated adult height.

Keywords: Bayley–Pinneau; Greulich and Pyle; Tanner Whitehouse; bone age; growth hormone; growth hormone deficiency; growth prediction

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