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Zhang D, da Silva DR, Garrett TJ, et al. Method Optimization: Analysis of Benzbromarone and Tolfenamic Acid in Citrus Tissues and Soil Using Liquid Chromatography Coupled With Triple-Quadrupole Mass Spectrometry. Front Plant Sci. 2020;11:222doi: 10.3389/fpls.2020.00222.
Zhang, D., da Silva, D. R., Garrett, T. J., Gonzalez, C. F., & Lorca, G. L. (2020). Method Optimization: Analysis of Benzbromarone and Tolfenamic Acid in Citrus Tissues and Soil Using Liquid Chromatography Coupled With Triple-Quadrupole Mass Spectrometry. Frontiers in plant science, 11222. https://doi.org/10.3389/fpls.2020.00222
Zhang, Dan, et al. "Method Optimization: Analysis of Benzbromarone and Tolfenamic Acid in Citrus Tissues and Soil Using Liquid Chromatography Coupled With Triple-Quadrupole Mass Spectrometry." Frontiers in plant science vol. 11 (2020): 222. doi: https://doi.org/10.3389/fpls.2020.00222
Zhang D, da Silva DR, Garrett TJ, Gonzalez CF, Lorca GL. Method Optimization: Analysis of Benzbromarone and Tolfenamic Acid in Citrus Tissues and Soil Using Liquid Chromatography Coupled With Triple-Quadrupole Mass Spectrometry. Front Plant Sci. 2020 Mar 06;11:222. doi: 10.3389/fpls.2020.00222. eCollection 2020. PMID: 32210995; PMCID: PMC7068813.
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Front Plant Sci. 2020 Mar 06;11:222. doi: 10.3389/fpls.2020.00222. eCollection 2020.

Method Optimization: Analysis of Benzbromarone and Tolfenamic Acid in Citrus Tissues and Soil Using Liquid Chromatography Coupled With Triple-Quadrupole Mass Spectrometry.

Frontiers in plant science

Dan Zhang, Danilo R da Silva, Timothy J Garrett, Claudio F Gonzalez, Graciela L Lorca

Affiliations

  1. Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United States.
  2. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, United States.

PMID: 32210995 PMCID: PMC7068813 DOI: 10.3389/fpls.2020.00222

Abstract

Herein, an analytical method was developed for extraction and quantification of benzbromarone and tolfenamic acid in citrus and soil matrices using liquid-liquid extraction followed by liquid chromatography-triple quadrupole-tandem mass spectrometry analysis. The compounds were extracted using 0.1% formic acid in 6:4 ethyl acetate and n-hexane solution, and the analytes were separated using a mixture of 0.1% formic acid in ultrapure water and 0.1% formic acid in acetonitrile as mobile phase. A six-point in-matrix calibration curve was constructed providing good linearity with coefficients of determination

Copyright © 2020 Zhang, da Silva, Garrett, Gonzalez and Lorca.

Keywords: LC-MS/MS; agricultural products; benzbromarone; citrus; liquid-liquid extraction; tolfenamic acid

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