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Kawashima M, Kohno T, Fujimori S, et al. Feasibility of autologous fibrin glue in general thoracic surgery. J Thorac Dis. 2020;12(3):484-492doi: 10.21037/jtd.2020.01.01.
Kawashima, M., Kohno, T., Fujimori, S., Kimura, N., Suzuki, S., Yoshimura, R., Yuhara, S., Kohno, A., Wakatabe, M., & Makino, S. (2020). Feasibility of autologous fibrin glue in general thoracic surgery. Journal of thoracic disease, 12(3), 484-492. https://doi.org/10.21037/jtd.2020.01.01
Kawashima, Mitsuaki, et al. "Feasibility of autologous fibrin glue in general thoracic surgery." Journal of thoracic disease vol. 12,3 (2020): 484-492. doi: https://doi.org/10.21037/jtd.2020.01.01
Kawashima M, Kohno T, Fujimori S, Kimura N, Suzuki S, Yoshimura R, Yuhara S, Kohno A, Wakatabe M, Makino S. Feasibility of autologous fibrin glue in general thoracic surgery. J Thorac Dis. 2020 Mar;12(3):484-492. doi: 10.21037/jtd.2020.01.01. PMID: 32274115; PMCID: PMC7139074.
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J Thorac Dis. 2020 Mar;12(3):484-492. doi: 10.21037/jtd.2020.01.01.

Feasibility of autologous fibrin glue in general thoracic surgery.

Journal of thoracic disease

Mitsuaki Kawashima, Tadasu Kohno, Sakashi Fujimori, Naoko Kimura, Souichiro Suzuki, Ryuichi Yoshimura, Shinji Yuhara, Akira Kohno, Makoto Wakatabe, Shigeyoshi Makino

Affiliations

  1. Department of Thoracic Surgery, Respiratory Center, Toranomon Hospital, Tokyo, Japan.
  2. Department of Transfusion Medicine, Toranomon Hospital, Tokyo, Japan.

PMID: 32274115 PMCID: PMC7139074 DOI: 10.21037/jtd.2020.01.01

Abstract

BACKGROUND: Fibrin glue effectively controls air leakage in lung surgery; however, allogenic fibrin glue cannot eliminate the risks of infection and allergy despite current sterilization methods. Autologous fibrin glue (AFG) could be a good alternative, but is not commonly used worldwide because of its limited availability and lack of evidence. Herein, we report clinical outcomes of AFG in thoracic surgery.

METHODS: We retrospectively analyzed patients who underwent lobectomies or segmentectomies between November 2016 and September 2017 in our institution. We used two types of AFGs. One was a partially-autologous fibrin glue (PAFG), the components of which are largely autologous but which contains allogenic thrombin. The other was a completely-autologous fibrin glue (CAFG) which has no allogenic components. PAFG was used in the first half of the study period, after which CAFG was used from March 2017 onward. Patients who did not undergo AFG generation were categorized as the non-AFG group. The perioperative outcomes of the three groups were evaluated.

RESULTS: A total of 207 patients underwent lung surgery, including 118 lobectomies and 89 segmentectomies. Among them, 83 patients received PAFG, 94 received CAFG, and 30 received non-AFG. The mean postoperative drainage period was within a few days in each group (PAFG

CONCLUSIONS: The use of AFG is clinically feasible for patients who undergo lobectomies or segmentectomies. AFGs could be a viable alternative to conventional allogenic fibrin glues.

2020 Journal of Thoracic Disease. All rights reserved.

Keywords: Fibrin tissue adhesive; lung neoplasms; pulmonary surgical procedures; thoracic surgery

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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