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Kim H, Lee SJ, Yoon M. Alpha-fetoprotein is correlated with intrahepatic recurrence of hepatocellular carcinoma after a hepatectomy. Ann Surg Treat Res. 2020;98(4):168-176doi: 10.4174/astr.2020.98.4.168.
Kim, H., Lee, S. J., & Yoon, M. (2020). Alpha-fetoprotein is correlated with intrahepatic recurrence of hepatocellular carcinoma after a hepatectomy. Annals of surgical treatment and research, 98(4), 168-176. https://doi.org/10.4174/astr.2020.98.4.168
Kim, Hyunyou, et al. "Alpha-fetoprotein is correlated with intrahepatic recurrence of hepatocellular carcinoma after a hepatectomy." Annals of surgical treatment and research vol. 98,4 (2020): 168-176. doi: https://doi.org/10.4174/astr.2020.98.4.168
Kim H, Lee SJ, Yoon M. Alpha-fetoprotein is correlated with intrahepatic recurrence of hepatocellular carcinoma after a hepatectomy. Ann Surg Treat Res. 2020 Apr;98(4):168-176. doi: 10.4174/astr.2020.98.4.168. Epub 2020 Mar 31. PMID: 32274364; PMCID: PMC7118319.
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Ann Surg Treat Res. 2020 Apr;98(4):168-176. doi: 10.4174/astr.2020.98.4.168. Epub 2020 Mar 31.

Alpha-fetoprotein is correlated with intrahepatic recurrence of hepatocellular carcinoma after a hepatectomy.

Annals of surgical treatment and research

Hyunyou Kim, So Jeong Lee, Myunghee Yoon

Affiliations

  1. Department of Surgery, Pusan National University Hospital, Busan, Korea.
  2. Department of Pathology, Pusan National University Hospital, Busan, Korea.

PMID: 32274364 PMCID: PMC7118319 DOI: 10.4174/astr.2020.98.4.168

Abstract

PURPOSE: Intrahepatic recurrence has a significant effect on the survival of hepatocellular carcinoma (HCC) patients. We aimed to determine if there are useful indicators in predicting the recurrence of liver cancer after a hepatic resection.

METHODS: We retrospectively reviewed medical records of 210 HCC patients who underwent hepatectomy between January 2009 and December 2015. We examined clinic-pathological variables comparing 2 groups of HCC patients, either intrahepatic recurrence or not.

RESULTS: We divided 184 patients into 2 groups; 94 patients (51.1%) with intrahepatic recurrence and 90 patients (48.9%) without intrahepatic recurrence. Multivariate analysis showed operation type, preoperative α-FP, postoperative protein induced by vitamin K absence-II (PIVKA-II) elevation, and multiple tumor number were closely associated with intrahepatic recurrence. The preoperative PIVKA-II level was not statistically significant in postoperative intrahepatic recurrence rate. The recurrence rate was 46.2% in 132 of 184 cases of α-FP < 100 ng/mL group. Of the 184 cases, α-FP 100-200 ng/mL were 14 cases (12 cases recurred (85.7%)). Alpha-fetoprotein > 200 ng/mL was 38 of 184 cases, 21 of which recurred (55.3%). According to the multivariate analysis, OR ratio was 8.003 (95% confidence interval [CI], 1.549-41.353) in the α-FP 100-200 ng/mL group and 1.867 (95% CI, 0.784-4.444) in α-FP 200 ng/mL or higher group (P = 0.013). Three-year survival rate of intrahepatic recurrence patients was 80.7%, 3-year survival rate of no intrahepatic recurrence patients was 95.0%.

CONCLUSION: The intrahepatic recurrence rates were high in the group preop α-FP over 100 ng/mL. Close observation is needed. Prospective study for α-FP genes of HCC patients should be planned for predicting intrahepatic recurrence after hepatectomy.

Copyright © 2020, the Korean Surgical Society.

Keywords: Alpha-fetoproteins; Hepatocellular carcinoma; Recurrence; Survival

Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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