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Onnis A, Cassioli C, Finetti F, et al. Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC. Front Cell Dev Biol. 2020;8:193doi: 10.3389/fcell.2020.00193.
Onnis, A., Cassioli, C., Finetti, F., & Baldari, C. T. (2020). Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC. Frontiers in cell and developmental biology, 8193. https://doi.org/10.3389/fcell.2020.00193
Onnis, Anna, et al. "Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC." Frontiers in cell and developmental biology vol. 8 (2020): 193. doi: https://doi.org/10.3389/fcell.2020.00193
Onnis A, Cassioli C, Finetti F, Baldari CT. Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC. Front Cell Dev Biol. 2020 Mar 26;8:193. doi: 10.3389/fcell.2020.00193. eCollection 2020. PMID: 32274384; PMCID: PMC7113388.
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Front Cell Dev Biol. 2020 Mar 26;8:193. doi: 10.3389/fcell.2020.00193. eCollection 2020.

Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC.

Frontiers in cell and developmental biology

Anna Onnis, Chiara Cassioli, Francesca Finetti, Cosima T Baldari

Affiliations

  1. Department of Life Sciences, University of Siena, Siena, Italy.

PMID: 32274384 PMCID: PMC7113388 DOI: 10.3389/fcell.2020.00193

Abstract

p66SHC is a pro-oxidant member of the SHC family of protein adaptors that acts as a negative regulator of cell survival. In lymphocytes p66SHC exploits both its adaptor and its reactive oxygen species (ROS)-elevating function to antagonize mitogenic and survival signaling and promote apoptosis. As a result, p66SHC deficiency leads to the abnormal expansion of peripheral T and B cells and lupus-like autoimmunity. Additionally, a defect in p66SHC expression is a hallmark of B cell chronic lymphocytic leukemia, where it contributes to the accumulation of long-lived neoplastic cells. We have recently provided evidence that p66SHC exerts a further layer of control on B cell homeostasis by acting as a new mitochondrial LC3-II receptor to promote the autophagic demise of dysfunctional mitochondria. Here we discuss this finding in the context of the autophagic control of B cell homeostasis, development, and differentiation in health and disease.

Copyright © 2020 Onnis, Cassioli, Finetti and Baldari.

Keywords: B lymphocytes; ROS; autophagy; mitophagy; p66SHC

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