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Ekblom-Bak E, Halldin M, Vikström M, et al. Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds. Eur J Prev Cardiol. 2020;2047487320916596doi: 10.1177/2047487320916596.
Ekblom-Bak, E., Halldin, M., Vikström, M., Stenling, A., Gigante, B., de Faire, U., Leander, K., & Hellénius, M. L. (2020). Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds. European journal of preventive cardiology, 2047487320916596. https://doi.org/10.1177/2047487320916596
Ekblom-Bak, Elin, et al. "Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds." European journal of preventive cardiology vol. (2020): 2047487320916596. doi: https://doi.org/10.1177/2047487320916596
Ekblom-Bak E, Halldin M, Vikström M, Stenling A, Gigante B, de Faire U, Leander K, Hellénius ML. Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds. Eur J Prev Cardiol. 2020 Apr 10;2047487320916596. doi: 10.1177/2047487320916596. Epub 2020 Apr 10. PMID: 32276576.
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Eur J Prev Cardiol. 2020 Apr 10;2047487320916596. doi: 10.1177/2047487320916596. Epub 2020 Apr 10.

Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds.

European journal of preventive cardiology

Elin Ekblom-Bak, Mats Halldin, Max Vikström, Andreas Stenling, Bruna Gigante, Ulf de Faire, Karin Leander, Mai-Lis Hellénius

Affiliations

  1. Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Sweden.
  2. Sophiahemmet Hospital, Sweden.
  3. Department of Cardiovascular Epidemiology, Karolinska Institutet, Sweden.
  4. Department of Psychology, Umeå University, Sweden.
  5. Department of Medicine, Karolinska Institutet, Sweden.

PMID: 32276576 DOI: 10.1177/2047487320916596

Abstract

AIMS: The purpose of this study was to analyse the association of leisure-time physical activity of different intensities at baseline, and cardiovascular disease incidence, cardiovascular disease mortality and all-cause mortality in a population-based sample of 60-year-old men and women with and without established metabolic syndrome, for more than 20 years of follow-up. A secondary aim was to study which cardiometabolic factors may mediate the association between physical activity and long-term outcomes.

METHODS: A total of 3693 participants (53% women) underwent physical examination and laboratory tests, completed an extensive questionnaire at baseline 1997-1999 and were followed until their death or until 31 December 2017. First-time cardiovascular disease events and death from any cause were ascertained through regular examinations of national registers.

RESULTS: Metabolic syndrome prevalence was 23.0%. In metabolic syndrome participants, light physical activity attenuated cardiovascular disease incidence (hazard ratio = 0.71; 95% confidence interval 0.50-1.00) compared to sedentary (reference) after multi-adjustment. Moderate/high physical activity was inversely associated with both cardiovascular disease and all-cause mortality, but became non-significant after multi-adjustment. Sedentary non-metabolic syndrome participants had lower cardiovascular disease incidence (0.47; 0.31-0.72) but not significantly different cardiovascular disease (0.61; 0.31-1.19) and all-cause mortality (0.92; 0.64-1.34) compared to sedentary metabolic syndrome participants. Both light and moderate/high physical activity were inversely associated with cardiovascular disease and all-cause mortality in non-metabolic syndrome participants (

CONCLUSION: Physical activity of different intensities attenuated cardiovascular risk and mortality in 60-year old men and women with metabolic syndrome during a 20-year follow-up.

Keywords: Prospective study; cardiovascular risk; metabolic syndrome; physical activity; prevention.; sedentary

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