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Sreedharan RM, Kesavadas C, Aiyappan S, et al. Functional Language Network Connectivity in Children of Women with Epilepsy with Selective Antenatal Antiepileptic Drug Exposure. Ann Indian Acad Neurol. 2020;23(2):167-173doi: 10.4103/aian.AIAN_402_19.
Sreedharan, R. M., Kesavadas, C., Aiyappan, S., Anila, K. M., Mohan, A. C., & Thomas, S. V. (2020). Functional Language Network Connectivity in Children of Women with Epilepsy with Selective Antenatal Antiepileptic Drug Exposure. Annals of Indian Academy of Neurology, 23(2), 167-173. https://doi.org/10.4103/aian.AIAN_402_19
Sreedharan, Ruma Madhu, et al. "Functional Language Network Connectivity in Children of Women with Epilepsy with Selective Antenatal Antiepileptic Drug Exposure." Annals of Indian Academy of Neurology vol. 23,2 (2020): 167-173. doi: https://doi.org/10.4103/aian.AIAN_402_19
Sreedharan RM, Kesavadas C, Aiyappan S, Anila KM, Mohan AC, Thomas SV. Functional Language Network Connectivity in Children of Women with Epilepsy with Selective Antenatal Antiepileptic Drug Exposure. Ann Indian Acad Neurol. 2020 Mar-Apr;23(2):167-173. doi: 10.4103/aian.AIAN_402_19. Epub 2020 Feb 26. PMID: 32189856; PMCID: PMC7061501.
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Ann Indian Acad Neurol. 2020 Mar-Apr;23(2):167-173. doi: 10.4103/aian.AIAN_402_19. Epub 2020 Feb 26.

Functional Language Network Connectivity in Children of Women with Epilepsy with Selective Antenatal Antiepileptic Drug Exposure.

Annals of Indian Academy of Neurology

Ruma Madhu Sreedharan, Chandrasekharan Kesavadas, Subramonium Aiyappan, K M Anila, Amitha C Mohan, Sanjeev V Thomas

Affiliations

  1. Department of Radiology, Government Medical College Hospital, Trivandrum, Kerala, India.
  2. Department of Imaging Science and Interventional Radiology, SCTIMST, Trivandrum, Kerala, India.
  3. Department of Neurology, SCTIMST, Trivandrum, Kerala, India.

PMID: 32189856 PMCID: PMC7061501 DOI: 10.4103/aian.AIAN_402_19

Abstract

PURPOSE: Children of women with epilepsy and antenatal antiepileptic drug (AED) exposure have increased risk of language dysfunction. Our objective was to compare language related functional MRI network connectivity (FC) of children with women with epilepsy with antenatal AED exposure (CAED) with that of healthy children (COAED) for delineating functional basis of the language dysfunction.

METHODS: CAED under prospective follow up in Kerala Registry of Epilepsy and Pregnancy were consecutively sampled. COAED were identified from volunteers with normal brain MRI. Clinical Evaluation of Language Fundamentals score (CELF) was used to assess language. Functional MRI done using verb generation paradigm to activate language areas and key language network nodes were identified. A multivariate ROI-to-ROI and Seed-to-Voxel based FC was done using the selected seed regions in the language areas located in the right and left hemisphere in all subjects using the CONN functional connectivity toolbox in SPM8 under MATLAB.

RESULTS: Strong connectivity was observed within the identified language network between all language nodes bilaterally in CAED compare to controls. The mean connectivity strength of language network (LN) on the left side in CAED was 9.63 ± 4.62 (Mean ± SD) while for COAED it was 6.96 ± 3.67 (p=0.0001). The mean connectivity strength of LN between CAED (4.86 ± 1.07) and COAED (4.32 ±1.2) on the right hemisphere was not statistically significant (p=0.18).

CONCLUSION: CAED with impaired language function had significantly increased functional connectivity which may indicate poor differentiation and localization of language centers.

Copyright: © 2020 Annals of Indian Academy of Neurology.

Keywords: Antiepileptic drugs; children of women with epilepsy; functional MRI; functional connectivity; language network

Conflict of interest statement

There are no conflicts of interest.

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