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Lancellotta V, De Felice F, Vicenzi L, et al. The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review. J Contemp Brachytherapy. 2020;12(1):61-66doi: 10.5114/jcb.2020.92698.
Lancellotta, V., De Felice, F., Vicenzi, L., Antonacci, A., Cerboneschi, V., Costantini, S., di Cristino, D., Tagliaferri, L., Cerrotta, A., Vavassori, A., Gribaudo, S., Colombo, A., Lucà, F., Barbara, R., Mangoni, M., Marampon, F., Musio, D., Bellati, F., Torcia, F., Tombolini, V., Osti, M. F., & De Sanctis, V. (2020). The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review. Journal of contemporary brachytherapy, 12(1), 61-66. https://doi.org/10.5114/jcb.2020.92698
Lancellotta, Valentina, et al. "The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review." Journal of contemporary brachytherapy vol. 12,1 (2020): 61-66. doi: https://doi.org/10.5114/jcb.2020.92698
Lancellotta V, De Felice F, Vicenzi L, Antonacci A, Cerboneschi V, Costantini S, di Cristino D, Tagliaferri L, Cerrotta A, Vavassori A, Gribaudo S, Colombo A, Lucà F, Barbara R, Mangoni M, Marampon F, Musio D, Bellati F, Torcia F, Tombolini V, Osti MF, De Sanctis V. The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review. J Contemp Brachytherapy. 2020 Feb;12(1):61-66. doi: 10.5114/jcb.2020.92698. Epub 2020 Feb 28. PMID: 32190072; PMCID: PMC7073340.
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J Contemp Brachytherapy. 2020 Feb;12(1):61-66. doi: 10.5114/jcb.2020.92698. Epub 2020 Feb 28.

The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review.

Journal of contemporary brachytherapy

Valentina Lancellotta, Francesca De Felice, Lisa Vicenzi, Alfredo Antonacci, Valentina Cerboneschi, Sara Costantini, Daniela di Cristino, Luca Tagliaferri, Annamaria Cerrotta, Andrea Vavassori, Sergio Gribaudo, Alessandro Colombo, Francesco Lucà, Raffaele Barbara, Monica Mangoni, Francesco Marampon, Daniela Musio, Filippo Bellati, Francesco Torcia, Vincenzo Tombolini, Mattia Falchetto Osti, Vitaliana De Sanctis

Affiliations

  1. Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia - Gemelli ART (Advanced Radiation Therapy), Interventional Oncology Center (IOC), Roma, Italy.
  2. Department of Radiological, Oncological and Anatomo Pathological Sciences, Azienda Ospedaliero Universitaria Policlinico Umberto I, "Sapienza" University, Rome, Italy.
  3. Radiotherapy Unit, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy.
  4. Radiotherapy Unit, S. Spirito Hospital, Pescara, Italy.
  5. Radiotherapy Unit, Department of Oncology, San Luca Hospital, Lucca, Italy.
  6. Radiotherapy Unit, Presidio Ospedaliero San Filippo Neri, Roma, Italy.
  7. Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  8. Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy.
  9. Department of Oncology-Radiotherapy, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.
  10. Division of Radiation Oncology, ASST-Lecco, Ospedale A.Manzoni, Lecco, Italy.
  11. Presidente Fondazione Area Radiologica, Roma, Italy.
  12. UOC Radioterapia Oncologica, Azienda Ospedaliera "Brotzu", Cagliari, Italy.
  13. Radiotherapy Unit, Dipartimento di Scienze Biomediche, Sperimentali e Cliniche Mario Serio, University of Florence, Firenze, Italy.
  14. Department of Medicine and Surgery and Translational Medicine, Gynecology Unit, Sant' Andrea University Hospital, "Sapienza" University, Rome, Italy.
  15. Department of Medicine and Surgery and Translational Medicine, Radiotherapy Oncology, Sant' Andrea Hospital, "Sapienza" University, Rome, Italy.

PMID: 32190072 PMCID: PMC7073340 DOI: 10.5114/jcb.2020.92698

Abstract

PURPOSE: Serous adenocarcinoma (uterine serous carcinoma - USC) is a rare and aggressive histologic subtype of endometrial cancer, with a high-rate of recurrence and poor prognosis. The adjuvant treatment for stage I patients is unclear. The purpose of this study was to evaluate the outcomes of stage I USC treated exclusively with chemotherapy plus vaginal brachytherapy (VBT).

MATERIAL AND METHODS: A systematic research using PubMed, Scopus, and Cochrane library was conducted to identify full articles evaluating the efficacy of VBT in patients with stage I USC. A search in ClinicalTrials.gov was performed in order to detect ongoing or recently completed trials, and in PROSPERO for searching ongoing or recently completed systematic reviews.

RESULTS: All studies were retrospective and 364 of evaluated patients were found. The average local control was 97.5% (range, 91-100%), the disease free-survival was 88% (range, 82-94%), the overall survival was 93% (range, 72-100%), the specific cancer survival was 89.4% (range, 84.8-94%), and the G3-G4 toxicity was 0-8%.

CONCLUSIONS: These data support the concept that in adequately selected patients, VBT alone may be a suitable radiotherapy technique in women with stage I USC who underwent surgical staging and received adjuvant chemotherapy.

Copyright © 2020 Termedia.

Keywords: brachytherapy; endometrial cancer; outcomes; serous adenocarcinoma

Conflict of interest statement

The authors report no conflict of interest.

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