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Mitsias DI, Dimou MV, Lakoumentas J, et al. Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes. Clin Transl Allergy. 2020;10:9doi: 10.1186/s13601-020-00313-2.
Mitsias, D. I., Dimou, M. V., Lakoumentas, J., Alevizopoulos, K., Sousa-Pinto, B., Fonseca, J. A., Bousquet, J., & Papadopoulos, N. G. (2020). Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes. Clinical and translational allergy, 109. https://doi.org/10.1186/s13601-020-00313-2
Mitsias, Dimitrios I, et al. "Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes." Clinical and translational allergy vol. 10 (2020): 9. doi: https://doi.org/10.1186/s13601-020-00313-2
Mitsias DI, Dimou MV, Lakoumentas J, Alevizopoulos K, Sousa-Pinto B, Fonseca JA, Bousquet J, Papadopoulos NG. Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes. Clin Transl Allergy. 2020 Mar 13;10:9. doi: 10.1186/s13601-020-00313-2. eCollection 2020. PMID: 32190296; PMCID: PMC7068957.
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Clin Transl Allergy. 2020 Mar 13;10:9. doi: 10.1186/s13601-020-00313-2. eCollection 2020.

Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes.

Clinical and translational allergy

Dimitrios I Mitsias, Maria V Dimou, John Lakoumentas, Konstantinos Alevizopoulos, Bernardo Sousa-Pinto, Joao A Fonseca, Jean Bousquet, Nikolaos G Papadopoulos

Affiliations

  1. 1Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital "P&A Kyriakou", University of Athens, Thivon and Levadias 1, Athens, Greece.
  2. Gerolymatos Int.S.A., Krioneri, Greece.
  3. 3CINTESIS, Center for Research in Health Technology and Information Systems, Faculty of Medicine, University of Porto, Porto, Portugal.
  4. 4MEDCIDS, Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
  5. MACVIA-France, Fondation Partenariale FMC VIA-LR, Montpellier, France.
  6. 6Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, UK.

PMID: 32190296 PMCID: PMC7068957 DOI: 10.1186/s13601-020-00313-2

Abstract

BACKGROUND: Nasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.

METHODS: An open-label, controlled, non-randomized, real-life study was conducted to evaluate the effectiveness of NI with a new hypertonic solution as add-on treatment for AR. Children and adolescents with AR were prescribed symptomatic treatment. The active group also received an additional sea-water NI solution supplemented with algae extracts. The primary endpoint was symptom control, assessed by the control of allergic rhinitis and asthma test (CARAT) questionnaires. Moreover, the MASK/Allergy Diary was used to track symptoms and daily medication use that were combined in a novel total symptom/medication score (TSMS).

RESULTS: We assessed 76 patients. Overall, there was a significant improvement of CARAT results (median Z-score change of 1.1 in the active/NI group vs. 0.4 in the control group;

CONCLUSION: Addition of NI with a sea-water solution to regular treatment improved AR symptom control. CARAT questionnaires and MASK application can be useful outcome tools in real-life studies.

© The Author(s) 2020.

Keywords: Allergic rhinitis; CARAT questionnaire; Children and adolescents; MASK/Allergy Diary app; Medication score; Nasal irrigations; Sea-water solution; Spirulina platensis; Symptom score; Undaria pinnatifida

Conflict of interest statement

Competing interestsDIM has received honoraria from Gerolymatos Int.S.A. MVD and JL have no declared conflicts of interest. KA is a consultant/scientific advisory board member for Gerolymatos Int.S.A.

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