Display options
Cite
Mehra R, Marnila P, Korhonen H. Milk immunoglobulins for health promotion. Int Dairy J. 2006;16(11):1262-1271doi: 10.1016/j.idairyj.2006.06.003.
Mehra, R., Marnila, P., & Korhonen, H. (2006). Milk immunoglobulins for health promotion. International dairy journal, 16(11), 1262-1271. https://doi.org/10.1016/j.idairyj.2006.06.003
Mehra, Raj, et al. "Milk immunoglobulins for health promotion." International dairy journal vol. 16,11 (2006): 1262-1271. doi: https://doi.org/10.1016/j.idairyj.2006.06.003
Mehra R, Marnila P, Korhonen H. Milk immunoglobulins for health promotion. Int Dairy J. 2006 Nov;16(11):1262-1271. doi: 10.1016/j.idairyj.2006.06.003. Epub 2006 Aug 21. PMID: 32288340; PMCID: PMC7135675.
Copy Download .nbib Format: NLM
Share it on

Int Dairy J. 2006 Nov;16(11):1262-1271. doi: 10.1016/j.idairyj.2006.06.003. Epub 2006 Aug 21.

Milk immunoglobulins for health promotion.

International dairy journal

Raj Mehra, Pertti Marnila, Hannu Korhonen

Affiliations

  1. Moorepark Food Research Centre, Teagasc, Fermoy, Co. Cork, Ireland.
  2. MTT Agrifood Research Finland, Biotechnology and Food Research, 31600 Jokioinen, Finland.

PMID: 32288340 PMCID: PMC7135675 DOI: 10.1016/j.idairyj.2006.06.003

Abstract

The biological function of bovine colostral immunoglobulins is to provide the newborn calf with adequate passive immune protection against microbial infections. Immunoglobulin preparations designed for farm animals are commercially available, and some colostrum-based products are marketed also for humans as dietary supplements. The concentration of specific antibodies against a certain pathogenic microorganism can be raised in colostrum and milk by immunizing cows with this pathogen or its antigen. Advances in bioseparation and chromatographic techniques have made it possible to fractionate and enrich these antibodies and formulate so-called hyperimmune colostral or milk preparations. Their efficacy in prevention and treatment of various microbial infections has been evaluated in numerous studies. Immune milk preparations have proven effective in prophylaxis against infections caused by a variety of gastrointestinal pathogens. Their therapeutic efficacy, however, seems more limited. A few commercial immune milk products are already on market and more applications can be expected in the coming years. This article reviews the recent progress made in isolation techniques of bovine immunoglobulins and the application of colostral and immune milk preparations in fighting various microbial infectious diseases in humans.

Copyright © 2006 Elsevier Ltd. All rights reserved.

Keywords: Antibody; Applications; Immune milk; Immunoglobulins; Isolation

References

  1. J Dairy Res. 1999 Feb;66(1):131-7 - PubMed
  2. Helicobacter. 2003 Jun;8(3):192-201 - PubMed
  3. J Clin Gastroenterol. 2005 Sep;39(8):692-8 - PubMed
  4. Shock. 2002 Jan;17(1):9-12 - PubMed
  5. Vaccine. 1997 Aug;15(11):1261-8 - PubMed
  6. Altern Med Rev. 2003 Nov;8(4):378-94 - PubMed
  7. Acta Paediatr. 2001 Dec;90(12):1373-8 - PubMed
  8. Oral Microbiol Immunol. 2002 Feb;17(1):9-15 - PubMed
  9. Lancet. 1989 Sep 23;2(8665):709-12 - PubMed
  10. Curr Opin Infect Dis. 2001 Jun;14(3):295-300 - PubMed
  11. J Dairy Sci. 1988 Jul;71(7):1747-55 - PubMed
  12. Arch Oral Biol. 2002 Nov;47(11):799-804 - PubMed
  13. Am J Clin Nutr. 2005 Apr;81(4):792-8 - PubMed
  14. J Dairy Sci. 2004 Feb;87(2):316-20 - PubMed
  15. Clin Pharmacokinet. 1997 Apr;32(4):313-23 - PubMed
  16. J Dairy Sci. 1998 Jan;81(1):54-63 - PubMed
  17. Scand J Gastroenterol. 2002 Dec;37(12):1380-5 - PubMed
  18. Infect Immun. 2002 May;70(5):2721-4 - PubMed
  19. J Dairy Sci. 2003 Jan;86(1):133-7 - PubMed
  20. Pediatrics. 1991 Feb;87(2):208-14 - PubMed
  21. Can Vet J. 1993 Jul;34(7):407-12 - PubMed
  22. Int J Infect Dis. 2003 Jun;7(2):120-8 - PubMed
  23. Caries Res. 2001 Nov-Dec;35(6):412-20 - PubMed
  24. Microbiol Immunol. 2002;46(11):761-6 - PubMed
  25. Infect Immun. 1998 May;66(5):2018-25 - PubMed
  26. Wien Klin Wochenschr. 2002 Nov 30;114(21-22):923-8 - PubMed
  27. Vaccine. 2002 May 15;20(16):2027-44 - PubMed
  28. J Dairy Sci. 2002 Apr;85(4):774-81 - PubMed
  29. J Agric Food Chem. 2005 Feb 9;53(3):663-70 - PubMed
  30. Antimicrob Agents Chemother. 1997 Feb;41(2):236-41 - PubMed
  31. J Dairy Res. 1998 Nov;65(4):599-607 - PubMed
  32. J Appl Bacteriol. 1993 May;74(5):564-9 - PubMed
  33. J Pediatr Gastroenterol Nutr. 2001 Feb;32(2):162-7 - PubMed
  34. Eur J Nutr. 2003 Aug;42(4):228-32 - PubMed
  35. J Dairy Sci. 2004 Dec;87(12):4073-9 - PubMed
  36. Am J Clin Nutr. 2004 Sep;80(3):737-41 - PubMed
  37. Regul Toxicol Pharmacol. 2005 Mar;41(2):102-12 - PubMed
  38. J Med Microbiol. 2005 Feb;54(Pt 2):197-205 - PubMed
  39. Biotechnol Bioeng. 2004 Aug 5;87(3):274-85 - PubMed
  40. Br J Nutr. 2000 Nov;84 Suppl 1:S135-46 - PubMed
  41. Clin Diagn Lab Immunol. 2001 Nov;8(6):1136-9 - PubMed
  42. Eur J Oral Sci. 1999 Aug;107(4):244-50 - PubMed
  43. J Clin Chem Clin Biochem. 1990 Jan;28(1):19-23 - PubMed

Publication Types