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Duffey K, Hannon M, Yoo J, et al. The impact of risk factors on gastroparesis at an urban medical center. Ann Gastroenterol. 2020;33(3):250-256doi: 10.20524/aog.2020.0475.
Duffey, K., Hannon, M., Yoo, J., Perkons, N., Intenzo, C., Moleski, S., & DiMarino, A. J. (2020). The impact of risk factors on gastroparesis at an urban medical center. Annals of gastroenterology, 33(3), 250-256. https://doi.org/10.20524/aog.2020.0475
Duffey, Katherine, et al. "The impact of risk factors on gastroparesis at an urban medical center." Annals of gastroenterology vol. 33,3 (2020): 250-256. doi: https://doi.org/10.20524/aog.2020.0475
Duffey K, Hannon M, Yoo J, Perkons N, Intenzo C, Moleski S, DiMarino AJ. The impact of risk factors on gastroparesis at an urban medical center. Ann Gastroenterol. 2020 May-Jun;33(3):250-256. doi: 10.20524/aog.2020.0475. Epub 2020 Apr 02. PMID: 32382227; PMCID: PMC7196617.
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Ann Gastroenterol. 2020 May-Jun;33(3):250-256. doi: 10.20524/aog.2020.0475. Epub 2020 Apr 02.

The impact of risk factors on gastroparesis at an urban medical center.

Annals of gastroenterology

Katherine Duffey, Michelle Hannon, Joseph Yoo, Nicholas Perkons, Charles Intenzo, Stephanie Moleski, Anthony J DiMarino

Affiliations

  1. Department of Medicine, Division of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA (Katherine Duffey, Michelle Hannon).
  2. Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA (Joseph Yoo, Stephanie Moleski, Anthony J. DiMarino).
  3. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (Nicholas Perkons).
  4. Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Thomas Jefferson University, Philadelphia, PA (Charles Intenzo), USA.

PMID: 32382227 PMCID: PMC7196617 DOI: 10.20524/aog.2020.0475

Abstract

BACKGROUND: Gastroparesis is a complex and poorly understood disease. The literature is lacking with respect to the epidemiology of patient comorbidities and their effect on gastric emptying. We aimed to describe the most common comorbid conditions among patients with gastroparesis in an urban population and quantify the effect of these comorbidities on the severity of delayed gastric emptying (DGE).

METHODS: We examined the medical records of all patients diagnosed with gastroparesis at a quaternary care center between 2014 and 2015. The severity of DGE was analyzed after patients were stratified for possible causative etiologies. Likelihood ratio tests were used to assess the significance of demographic and scintigraphic variation in this population.

RESULTS: Of the 221 patients, 56.1% were Caucasian and 31.7% were African American. Among these patients, 29.4% had evidence of medication-associated gastroparesis, 29.0% had diabetes-associated gastroparesis, and 31.7% had idiopathic disease. African American patients with gastroparesis were more likely to have diabetic gastroparesis than patients of other races (P=0.01). There was a statistically significant relationship between the number of major risk factors and the severity of a patient's DGE (P=0.004).

CONCLUSIONS: Among a diverse urban population, patients with DGE often carry multiple comorbid conditions that serve as risk factors for the development of gastroparesis, including prescriptions for narcotic medications. Greater numbers of these comorbid conditions are associated with more severe disease. Demographics are significantly associated with the etiology and severity of gastroparesis; in particular, African American patients are more likely to have diabetic gastroparesis than patients of other races.

Copyright: © Hellenic Society of Gastroenterology.

Keywords: Delayed gastric emptying; diabetes mellitus; narcotic medications

Conflict of interest statement

Conflict of Interest: None

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