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Brenton JN, Kammeyer R, Gluck L, et al. Multiple Sclerosis in Children: Current and Emerging Concepts. Semin Neurol. 2020;40(2):192-200doi: 10.1055/s-0040-1703000.
Brenton, J. N., Kammeyer, R., Gluck, L., Schreiner, T., & Makhani, N. (2020). Multiple Sclerosis in Children: Current and Emerging Concepts. Seminars in neurology, 40(2), 192-200. https://doi.org/10.1055/s-0040-1703000
Brenton, J Nicholas, et al. "Multiple Sclerosis in Children: Current and Emerging Concepts." Seminars in neurology vol. 40,2 (2020): 192-200. doi: https://doi.org/10.1055/s-0040-1703000
Brenton JN, Kammeyer R, Gluck L, Schreiner T, Makhani N. Multiple Sclerosis in Children: Current and Emerging Concepts. Semin Neurol. 2020 Apr;40(2):192-200. doi: 10.1055/s-0040-1703000. Epub 2020 Apr 15. PMID: 32294785; PMCID: PMC8514113.
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Semin Neurol. 2020 Apr;40(2):192-200. doi: 10.1055/s-0040-1703000. Epub 2020 Apr 15.

Multiple Sclerosis in Children: Current and Emerging Concepts.

Seminars in neurology

J Nicholas Brenton, Ryan Kammeyer, Lauren Gluck, Teri Schreiner, Naila Makhani

Affiliations

  1. Department of Neurology, University of Virginia, Charlottesville, Virginia.
  2. Department of Pediatrics, University of Colorado, Aurora, Colorado.
  3. Department of Neurology, University of Colorado, Aurora, Colorado.
  4. Department of Pediatrics, Yale University, New Haven, Connecticut.
  5. Department of Neurology, Yale University, New Haven, Connecticut.

PMID: 32294785 PMCID: PMC8514113 DOI: 10.1055/s-0040-1703000

Abstract

Multiple sclerosis is being increasingly recognized and diagnosed in children. In the past several years, advances have been made in diagnosing multiple sclerosis in children, identifying new genetic and environmental risk factors, delineating underlying immunobiology, characterizing imaging findings, and implementing new treatment strategies. In this review, we discuss these advances. Future research into the determinants of multiple sclerosis in children and into new treatment options will be aided by continued international collaboration.

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Conflict of interest statement

N.M. reports grants from NIH/NINDS, during the conduct of the study.

References

  1. Mult Scler Relat Disord. 2017 Nov;18:56-59 - PubMed
  2. Neurology. 2017 Aug 29;89(9):900-908 - PubMed
  3. Brain. 2007 Oct;130(Pt 10):2589-95 - PubMed
  4. Lancet Neurol. 2011 May;10(5):436-45 - PubMed
  5. Neurology. 2015 Nov 10;85(19):1663-9 - PubMed
  6. Neurology. 2017 Apr 25;88(17):1623-1629 - PubMed
  7. Pediatr Neurol. 2016 Apr;57:101-4 - PubMed
  8. Mult Scler. 2019 Apr;25(4):515-522 - PubMed
  9. JAMA Neurol. 2013 Apr;70(4):469-75 - PubMed
  10. Ann Clin Transl Neurol. 2018 Sep 17;5(10):1222-1228 - PubMed
  11. Mult Scler. 2015 Jun;21(7):956-9 - PubMed
  12. BMC Neurol. 2015 Sep 25;15:174 - PubMed
  13. Neurology. 2013 Oct 15;81(16):1392-9 - PubMed
  14. Mult Scler. 2019 Jun;25(7):980-986 - PubMed
  15. Eur J Neurol. 2016 Jan;23 Suppl 1:18-27 - PubMed
  16. Neurology. 2009 Jun 16;72(24):2076-82 - PubMed
  17. Mult Scler. 2015 May;21(6):735-48 - PubMed
  18. PLoS One. 2014 Feb 26;9(2):e85741 - PubMed
  19. J Neurol. 2018 Jun;265(6):1310-1319 - PubMed
  20. J Neuroimaging. 2017 Sep;27(5):447-452 - PubMed
  21. Pediatr Neurol. 2015 Dec;53(6):503-7 - PubMed
  22. Neurol Sci. 2009 Jun;30(3):193-9 - PubMed
  23. J Child Neurol. 2013 Jul;28(7):849-56 - PubMed
  24. PLoS One. 2016 Jan 05;11(1):e0145906 - PubMed
  25. Mult Scler Relat Disord. 2014 Mar;3(2):186-93 - PubMed
  26. Pediatr Neurol. 2009 Aug;41(2):119-23 - PubMed
  27. N Engl J Med. 2018 Sep 13;379(11):1017-1027 - PubMed
  28. Pediatr Neurol. 2018 Jun;83:19-24 - PubMed
  29. Arch Neurol. 2009 Aug;66(8):967-71 - PubMed
  30. Lancet Neurol. 2018 Feb;17(2):162-173 - PubMed
  31. Mult Scler. 2018 Jul;24(8):1077-1086 - PubMed
  32. Neurology. 2011 Mar 1;76(9):781-6 - PubMed
  33. Acta Neurol Scand. 2016 Sep;134 Suppl 200:39-46 - PubMed
  34. PLoS Genet. 2009 Feb;5(2):e1000369 - PubMed
  35. Neurology. 2018 Oct 23;91(17):e1579-e1590 - PubMed
  36. Eur J Paediatr Neurol. 2013 Jan;17(1):50-4 - PubMed
  37. Mult Scler. 2012 Dec;18(12):1754-9 - PubMed
  38. Mult Scler. 2018 Jul;24(8):1067-1076 - PubMed
  39. Mult Scler Relat Disord. 2019 Jan;27:184-187 - PubMed
  40. Pediatr Neurol. 2018 Jan;78:70-74 - PubMed
  41. Pediatrics. 2017 Apr;139(4): - PubMed
  42. Mult Scler. 2019 Jun;25(7):927-936 - PubMed
  43. Pediatr Neurol. 2017 Oct;75:17-28 - PubMed
  44. Mult Scler. 2013 Jun;19(7):891-5 - PubMed
  45. Mult Scler. 2013 Sep;19(10):1310-9 - PubMed
  46. Neurology. 2006 Feb 28;66(4):472-6 - PubMed
  47. Radiology. 2010 Feb;254(2):541-50 - PubMed
  48. PLoS Genet. 2019 Jan 17;15(1):e1007808 - PubMed
  49. Ann Clin Transl Neurol. 2018 Sep 27;5(10):1146-1153 - PubMed
  50. Mult Scler. 2016 Feb;22(2):193-200 - PubMed
  51. Arch Neurol. 2009 Jan;66(1):54-9 - PubMed
  52. Neurology. 2013 Aug 27;81(9):784-92 - PubMed
  53. Mult Scler. 2017 May;23(6):818-829 - PubMed
  54. Ann Neurol. 2011 Jan;69(1):75-82 - PubMed
  55. Neurology. 2014 Jul 8;83(2):142-50 - PubMed
  56. Neurology. 2011 Jun 7;76(23):1989-95 - PubMed
  57. Autoimmun Rev. 2014 Sep;13(9):981-1000 - PubMed
  58. Pediatr Neurol. 2017 Dec;77:67-72 - PubMed
  59. Eur J Neurol. 2014 Mar;21(3):441-6 - PubMed
  60. Neurology. 2013 Dec 3;81(23):1996-2001 - PubMed
  61. Neurology. 2019 Apr 9;92(15):e1709-e1723 - PubMed
  62. Mult Scler Relat Disord. 2018 Oct;25:138-142 - PubMed
  63. J Neuroimmunol. 2016 Aug 15;297:1-8 - PubMed
  64. Neurology. 2013 Feb 5;80(6):548-52 - PubMed
  65. Pediatr Neurol. 2017 May;70:56-60 - PubMed
  66. Mult Scler Relat Disord. 2014 Nov;3(6):684-8 - PubMed
  67. AJNR Am J Neuroradiol. 2013 Oct;34(10):2015-20 - PubMed
  68. Eur J Paediatr Neurol. 2014 Mar;18(2):119-25 - PubMed
  69. Mult Scler. 2016 Mar;22(3):385-8 - PubMed
  70. Lancet Child Adolesc Health. 2018 Mar;2(3):191-204 - PubMed
  71. J Neurol Sci. 2015;353(1-2):107-10 - PubMed
  72. Mult Scler. 2009 May;15(5):627-31 - PubMed
  73. Neurology. 2014 Feb 11;82(6):470-3 - PubMed
  74. Clin Immunol. 2013 Mar;146(3):176-84 - PubMed
  75. Neurology. 2002 Dec 24;59(12):1922-8 - PubMed
  76. Neurotherapeutics. 2017 Oct;14(4):985-998 - PubMed
  77. Ann Neurol. 2010 May;67(5):618-24 - PubMed
  78. Neuroimage Clin. 2014 Sep 10;6:237-42 - PubMed
  79. Dev Med Child Neurol. 2019 Nov;61(11):1289-1294 - PubMed
  80. Neurology. 2016 Aug 30;87(9 Suppl 2):S67-73 - PubMed
  81. Neurology. 2014 Dec 2;83(23):2140-6 - PubMed
  82. J Neuroimmunol. 2010 Jun;223(1-2):92-9 - PubMed
  83. Neurology. 2018 Nov 6;91(19):e1778-e1787 - PubMed
  84. J Neurol Sci. 2016 Apr 15;363:33-8 - PubMed
  85. Mult Scler Relat Disord. 2016 Mar;6:87-92 - PubMed
  86. J Neurol Neurosurg Psychiatry. 2018 Jan;89(1):28-33 - PubMed
  87. Mult Scler J Exp Transl Clin. 2018 May 25;4(2):2055217318778610 - PubMed
  88. Neurology. 2016 Nov 15;87(20):2074-2081 - PubMed
  89. Brain. 2009 Dec;132(Pt 12):3392-400 - PubMed
  90. Lancet Neurol. 2007 Sep;6(9):773-81 - PubMed
  91. Ann Clin Transl Neurol. 2016 Nov 04;3(12):897-907 - PubMed

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