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Cabinio M, Rossetto F, Isernia S, et al. The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG). J Clin Med. 2020;9(5)doi: 10.3390/jcm9051355.
Cabinio, M., Rossetto, F., Isernia, S., Saibene, F. L., Di Cesare, M., Borgnis, F., Pazzi, S., Migliazza, T., Alberoni, M., Blasi, V., & Baglio, F. (2020). The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG). Journal of clinical medicine, 9(5), . https://doi.org/10.3390/jcm9051355
Cabinio, Monia, et al. "The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG)." Journal of clinical medicine vol. 9,5 (2020). doi: https://doi.org/10.3390/jcm9051355
Cabinio M, Rossetto F, Isernia S, Saibene FL, Di Cesare M, Borgnis F, Pazzi S, Migliazza T, Alberoni M, Blasi V, Baglio F. The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG). J Clin Med. 2020 May 06;9(5). doi: 10.3390/jcm9051355. PMID: 32384591; PMCID: PMC7290592.
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J Clin Med. 2020 May 06;9(5). doi: 10.3390/jcm9051355.

The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG).

Journal of clinical medicine

Monia Cabinio, Federica Rossetto, Sara Isernia, Francesca Lea Saibene, Monica Di Cesare, Francesca Borgnis, Stefania Pazzi, Tommaso Migliazza, Margherita Alberoni, Valeria Blasi, Francesca Baglio

Affiliations

  1. IRCCS Fondazione Don Carlo Gnocchi ONLUS, via Capecelatro 66, 20148 Milan, Italy.
  2. Consorzio di Bioingegneria e Informatica medica (CBIM), 27100 Pavia, Italy.

PMID: 32384591 PMCID: PMC7290592 DOI: 10.3390/jcm9051355

Abstract

Due to the lack of pharmacological treatment for dementia, timely detection of subjects at risk can be of seminal importance for preemptive rehabilitation interventions. The aim of the study was to determine the usability of the smart aging serious game (SASG), a virtual reality platform, in assessing the cognitive profile of an amnestic mild cognitive impairment (aMCI) population, its validity in discriminating aMCI from healthy controls (HC), and in detecting hippocampal degeneration, a biomarker of clinical progression towards dementia. Thirty-six aMCI and 107 HC subjects were recruited and administered the SASG together with a neuropsychological evaluation. All aMCI and 30 HC subjects performed also an MRI for hippocampal volume measurement. Results showed good usability of the SASG despite the low familiarity with technology in both groups. ROC curve analyses showed similar discriminating abilities for SASG and gold standard tests, and a greater discrimination ability compared to non-specific neuropsychological tests. Finally, linear regression analysis revealed that the SASG outperformed the Montreal cognitive assessment test (MoCA) in the ability to detect neuronal degeneration in the hippocampus on the right side. These data show that SASG is an ecological task, that can be considered a digital biomarker providing objective and clinically meaningful data about the cognitive profile of aMCI subjects.

Keywords: Alzheimer disease; MRI; cognitive rehabilitation; computerized assessment; dementia; digital biomarker; hippocampus; mild cognitive impairment; serious game; virtual reality

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